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Current Psychiatry Research and Reviews


ISSN (Print): 2666-0822
ISSN (Online): 2666-0830

Review Article

Combat Military Personnel and Selective Risk Factors for the Development of Dementias - A Review

Author(s): Blanka Klimova, Petra Maresova and Kamil Kuca*

Volume 15, Issue 1, 2019

Page: [44 - 48] Pages: 5

DOI: 10.2174/1573400515666190114155451

Price: $65


Due to the growth of life expectancies and the increasing number of elderly population all over the world, there is a risk of growth of aging diseases such as dementia. Recent research studies also indicate that there will be a growing number of military veterans who will be affected by dementia, already at the age of 55+ years. In the case of combat military personnel, the most common dementias are Alzheimer’s disease and vascular dementia. These two dementias are very similar because their main symptoms are the same. The purpose of this review is to explore two main risk factors influencing the development of the dementias. These include posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). Furthermore, the authors of this study focus on the exploration of the treatment of PTSD and TBI in order to delay the development of dementias among combat military personnel.

For the purpose of this study, a method of literature review of available sources exploring these two main risk factors of dementia among combat military personnel was used. Based on the evaluation of these literature sources, possibilities of pharmacological and non-pharmacological approaches to the treatment and care of these people were described.

Keywords: Soldiers, dementias, posttraumatic stress disorder, traumatic brain injury, treatment, Alzheimer's disease.

Graphical Abstract
Jorm AF, Jolley D. The incidence of dementia: a meta-analysis. Neurology 1998; 51: 728-33.
Prince M, Guerchet M, Prina M. Policy brief for heads of government: The global impact of dementia 2013-2050. London: Alzheimer’s Disease International Publishers 2013.
Byers AL, Yaffe K. Depression and dementias among military veterans. Alzheimers Dement 2014; 10: S166-73.
Byers AL, Covinsky KE, Barnes DE, Yaffe K. Dythymia and depression increase risk of dementia and mortality among older veterans. Am J Geriatr Psychiatry 2012; 20: 664-72.
Maresova P, Penhaker M, Selamat A, Kuca K. The potential of medical device industry in technological and economical context. Ther Clin Risk Manag 2015; 11: 1505-14.
Mohelska H, Maresova P, Valis M, Kuca K. Alzheimer disease and its treatment costs - case study in the Czech Republic. Neuropsychiatr Dis Treat 2015; 11: 2349-54.
Klimova B, Maresova P, Valis M, Hort J, Kuca K. Alzheimer’s disease and language impairments: social intervention and medical treatment. Clin Interv Aging 2015; 10: 1401-8.
Jagust W. Untangling vascular dementia. Lancet 2001; 358(9299): 2097.
Vascular dementia. Encyclopedia of Mental Disorders 2003; [accessed September 9, 2015.] Available at http.http: //www.minddisorders. com/Py-Z/Vascular-dementia.html#ixzz3gM8I77bq
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: American Psychiatric Publishing. 2003.
PTSD in military veterans; [accessed September 9, 2015] Available at http. http: //
Mayo Clinic. Posttraumatic stress disorder. Symptoms; 1998-2015; [accessed September 9, 2015]. Available at. http: //www.mayoclinic. org/diseases-conditions/post-traumatic-stress-disorder/basics/symptoms/con-20022540
Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol 2008; 7(8): 728-41.
Parikh S, Koch M, Narayan RK. Traumatic brain injury. Int Anesthesiol Clin 2007; 45(3): 119-35.
Weiner MW, Friedl KE, Pacifico A, et al. Military risk factors for Alzheimer’s disease. Alzheimers Dement 2013; 9: 445-51.
Mayo Clinic. Traumatic brain injury. Symptoms; 1998-2015; [accessed September 9, 2015]. Available at. http: //www.mayoclinic. org/diseases-conditions/traumatic-brain-injury/basics/symptoms/con-20029302
Okie S. Traumatic brain injury in the war zone. N Engl J Med 2005; 352: 2043-7.
McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement 2014; 10(3): S242-53.
Barnes D, Krueger K, Byers A, Diaz-Arrastia R, Yaffe K. Traumatic brain injury and risk of dementia in older veterans. Neurology 2014; S3(4): 312-9.
Stein TD, Montenigro PH, Alvarez VE, et al. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol 2015; 130(1): 21-34.
Hofmann SG, Smits JA. Cognitive-behavioral therapy for adult anxiety disorders: a metaanalysis of randomized placebo-controlled trials. J Clin Psychiatry 2008; 69(4): 621-32.
Jonas DE, Cusack K, Forneris CA, et al. Psychological and pharmacological treatments for adults with posttraumatic stress disorder (PTSD). Comp Effect Rev 2013; 92: 1-760.
Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol 2014; 28(5): 403-39.
Muscatello MR, Spina E, Bandelow B, Baldwin DS. Clinically relevant drug interactions in anxiety disorders. Hum Psychopharmacol 2012; 27: 239-53.
Baldwin DS, and Kosky N. Off-label prescribing in psychiatric practice. Adv Psychiatr Treat 2007; 13: 414-22.
Schatzberg A, Blier P, Delgado P, et al. Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research. J Clin Psychiatry 2006; 67: 27-30.
Tint A, Haddad PM, Anderson IM. The effect of rate of antidepressant tapering on the incidence of discontinuation symptoms: a randomised study. J Psychopharmacol 2008; 22: 330-2.
Baldwin DS, Waldman S, Allgulander C. Evidence-based pharmacological treatment of generalized anxiety disorder. Int J Neuropsychopharmacol 2011; 14: 697-710.
Thornton K, Carmody D. Efficacy of traumatic brain injury rehabilitation: interventions of QEEG-guided biofeedback, computers, strategies, and medications. Appl Psychophysiol Biofeedback 2008; 33(2): 101-24.
Moore AJ, Newell DV. Neurosurgery Principle and Practise. Berlin: Springer 2004.
Kuwahira K, Schimodozono M, Etoh S, Kamada K, Noma T, Tanaka N. Effects of intensive repetition of a new facilitation technique on motorfunctional recovery of the hemiplegic upper limb and hand. Brain Inj 2010; 10: 1202-13.
Dedding C, Cardol M, Eyssen I, Dekker J, Beelen A. Validity of the Canadian occupational performance measure: a client-centered outcome measurement. Clin Rehabil 2004; 18: 660-7.
Reiner R, Lunenburger L, Kolombo G. Human-centered robotics applied to gait training and assessment. J Rehabil Res Dev 2006; 5: 679-94.
Waldner A. Robot assisted therapy in neurorehabilitation. Eur Med Phys 2008; 44(Suppl.): 1-3.
Invisible wounds: serving service members and veterans with PTSD and TBI Washington. DC: National Council of Disability 2009.
Plassman BL, Havlik RJ, Steffens DC, et al. Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias. Neurology 2000; 55: 1158-66.
Yaffe K, Vittinghoff E, Lindquist K, et al. Posttraumatic stress disorder and risk of dementia among US veterans. Arch Gen Psychiatry 2010; 67: 608-13.
Weiner MW, Veitch DP, Hayes J, et al. Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer’s disease in veterans, using the Alzheimer’s disease neuroimaging initiative. Alzheimers Dement 2014; 10(3): S226-35.
Stevelink SAM, Malcolm EM, Mason C, Jenkins S, Sundin J, Fear NT. The prevalence of mental health disorders in (ex-)military prsonnel with a physical impairment: a systematic review. Occup Environ Med 2014; 72(4): 243-51.
Yaffe K, Hoang TD, Byers AL, Barnes DE, Friedl KE. Lifestyle and health-related risk factors and risk of cognitive aging among older veterans. Alzheimers Dement 2014; 10(3): S111-21.
Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 2011; 10: 819-28.
Veitch DP, Friedl EK, Weiner MW. Military risk factors for cognitive decline, dementia and Alzheimer’s disease. Curr Alzheimer Res 2013; 10: 907-30.

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