![conference banner](/images/conference-banner.jpeg)
Abstract
The signal transducer and activator of transcription (STAT) proteins and their mechanisms of signaling were originally discovered in the context of normal interferon signaling, where they have been shown to have specific roles in mediating host defenses. It is now known that many cytokines, hormones and growth factors utilize STAT signaling pathways to control a remarkable variety of biological responses, including development, differentiation, cell proliferation, and survival. Given the critical roles of STAT proteins in these fundamental cellular processes, which are often altered in cancer, there is accumulating evidence defining a critical role for STAT proteins in oncogenesis. Members of this relatively small family of proteins serve as both transducers of cytoplasmic signals and nuclear transcription factors, thereby directly converting a stimulus at the cell surface to an alteration in the genetic program. Moreover, STAT proteins can cross-talk with other central signaling pathways, such as the mitogen-activated protein kinase (MAPK) family of proteins and the nuclear receptor signaling pathways. On the othe r hand, other proteins are known to interact with and modulate STAT signaling pathways, including histone acetyl-transferases and the protein inhibitor of activated STAT (PIAS) family of protein. The present review will try to address some questions concerning the increasingly complex biological functions of STAT proteins, the many diverse mechanisms of STAT regulation and the expanding number of target genes that mediate the biological responses elicited by STAT signaling pathways.
Current Genomics
Title: STAT Signaling and Cell Function
Volume: 3 Issue: 5
Author(s): Fernando de Miguel and Allen C. Gao
Affiliation:
Abstract: The signal transducer and activator of transcription (STAT) proteins and their mechanisms of signaling were originally discovered in the context of normal interferon signaling, where they have been shown to have specific roles in mediating host defenses. It is now known that many cytokines, hormones and growth factors utilize STAT signaling pathways to control a remarkable variety of biological responses, including development, differentiation, cell proliferation, and survival. Given the critical roles of STAT proteins in these fundamental cellular processes, which are often altered in cancer, there is accumulating evidence defining a critical role for STAT proteins in oncogenesis. Members of this relatively small family of proteins serve as both transducers of cytoplasmic signals and nuclear transcription factors, thereby directly converting a stimulus at the cell surface to an alteration in the genetic program. Moreover, STAT proteins can cross-talk with other central signaling pathways, such as the mitogen-activated protein kinase (MAPK) family of proteins and the nuclear receptor signaling pathways. On the othe r hand, other proteins are known to interact with and modulate STAT signaling pathways, including histone acetyl-transferases and the protein inhibitor of activated STAT (PIAS) family of protein. The present review will try to address some questions concerning the increasingly complex biological functions of STAT proteins, the many diverse mechanisms of STAT regulation and the expanding number of target genes that mediate the biological responses elicited by STAT signaling pathways.
Export Options
About this article
Cite this article as:
Miguel de Fernando and Gao C. Allen, STAT Signaling and Cell Function, Current Genomics 2002; 3 (5) . https://dx.doi.org/10.2174/1389202023350318
DOI https://dx.doi.org/10.2174/1389202023350318 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
Genomic Insights into Oncology: Harnessing Machine Learning for Breakthroughs in Cancer Genomics.
This special issue aims to explore the cutting-edge intersection of genomics and oncology, with a strong emphasis on original data and experimental validation. While maintaining the focus on how machine learning and advanced data analysis techniques are revolutionizing our understanding and treatment of cancer, this issue will prioritize contributions that ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anticancer Mammalian Target of Rapamycin (mTOR) Signaling Pathway Inhibitors: Current Status, Challenges and Future Prospects in Management of Epilepsy
CNS & Neurological Disorders - Drug Targets Perturbation of HSP Network in MCF-7 Breast Cancer Cell Line Triggers Inducible HSP70 Expression and Leads to Tumor Suppression
Anti-Cancer Agents in Medicinal Chemistry Extracellular Matrix and Aberrant Signaling in Lung Carcinoma: Role of Fibronectin in the Control of Human Lung Carcinoma Cell Growth,Apoptosis and Resistance to Therapy
Current Signal Transduction Therapy A Phosphoproteomics Approach to Identify Candidate Kinase Inhibitor Pathway Targets in Lymphoma-Like Primary Cell Lines
Current Drug Discovery Technologies Network Pharmacology Analysis of Molecular Mechanism of Curcuma longa L. Extracts Regulating Glioma Immune Inflammatory Factors: Implications for Precise Cancer Treatment
Current Topics in Medicinal Chemistry The Emerging Role of EMT-related lncRNAs in Therapy Resistance and their Applications as Biomarkers
Current Medicinal Chemistry Drug Analogs of COX-2 Selective Inhibitors Lumiracoxib and Valdecoxib Derived from in silico Search and Optimization
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Eating Green: Shining Light on the Use of Dietary Phytochemicals as a Modern Approach in the Prevention and Treatment of Head and Neck Cancers
Current Topics in Medicinal Chemistry Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review
Current Medicinal Chemistry Synthetic and Medicinal Prospective of Structurally Modified Curcumins
Current Topics in Medicinal Chemistry Nanotechnology and Animal Health
Pharmaceutical Nanotechnology Recent Developments in the Field of Tumor-Inhibiting Metal Complexes
Current Pharmaceutical Design Pregnane X Receptor and its Potential Role in Drug Resistance in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Copper Transport Systems are Involved in Multidrug Resistance and Drug Transport
Current Medicinal Chemistry Anesthesia for Bronchoscopy
Current Pharmaceutical Design TRAIL Agonists on Clinical Trials for Cancer Therapy: The Promises and the Challenges
Reviews on Recent Clinical Trials Brain Tumor Causes, Symptoms, Diagnosis and Radiotherapy Treatment
Current Medical Imaging Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis
Current Pharmaceutical Design P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives
Current Cancer Drug Targets The Hepatocyte Growth Factor Receptor: Structure, Function and Pharmacological Targeting in Cancer
Current Signal Transduction Therapy