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摘要
对微生物病原体产生抗生素耐药性的新兴危机令所有国家感到震惊,对人类健康构成全球性威胁。 金属-β-内酰胺酶的产生是细菌产生抗性的最有效策略。 对抗这种全球健康威胁的有效方法是开发广泛/非特异性类型的金属-β-内酰胺酶抑制剂,其可以抑制酶的不同同种型。 到目前为止,还没有针对金属β-内酰胺酶的临床活性药物。 缺乏针对携带细菌的MBL的有效药物分子需要不断的研究努力以克服多药耐药细菌的问题。 本综述将讨论针对B1金属-β-内酰胺酶的不同变体的临床有效分子。
关键词: 抗生素抗性,B1金属-β-内酰胺酶,变体,酶,同种型,多药耐药细菌。
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