摘要
膜蛋白在体内起着重要的生理作用，是药物的主要靶点。膜蛋白的研究是药物发现的重要组成部分。生物过程是一个循环网络，膜蛋白是网络中的一个重要枢纽，因为大多数药物通过与膜蛋白的相互作用达到治疗效果。本文综述了典型的膜蛋白靶点，包括gpcrs、转运体和离子通道。此外，我们还总结了涉及药物、药物目标信息及其相关数据的网络服务器和数据库。此外，我们主要介绍了现代药物的发展和实践，特别是展示了一系列最先进的计算模型，包括基于网络的方法和基于机器学习的方法，并展示了当代的成果。最后，我们讨论了药物再利用和药物发现的未来方向，并提出了生物活性数据的改进框架、建立或改进的预测方法、药物生物活性的替代理解方法及其生物过程。
关键词: 膜蛋白，药物目标，药物发现，计算生物学，机器学习，生物网络。
图形摘要
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Call for Papers in Thematic Issues
08 December, 2024
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
18 November, 2024
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response, and/or therapy ...read more
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