![conference banner](/images/conference-banner.jpeg)
Abstract
Biaryls are a key structural motif in compounds with various applications, ranging from pharmaceuticals to material science, including ligands for organic synthesis. Given the growing concern about the use of transition metals in organic synthesis in terms of reaction condition mildness, substituents tolerance, reagents costs and toxicity, and purification of the products from metal traces, several alternatives have been developed to overcome the limitations of metal-catalyzed biaryls synthesis. Herein, we review the transition metal-free approaches to biaryls, which can be divided into metal-free crosscoupling of aromatics and metal-free benzannulation of aryl-substituted chains, as both fields have shown an impressive growth in recent years.
Keywords: Biaryls, metal-free, cross-coupling, diels-alder, annulation, oxidative coupling.
Current Organic Chemistry
Title:Transition Metal-free Approaches to Biaryls
Volume: 22 Issue: 26
Author(s): Francesca Piazzolla*, Francesco Colognese and Andrea Temperini
Affiliation:
- Dipartimento di Scienze Farmaceutiche, Universita degli studi di Perugia, via del Liceo 1, 06123, Perugia,Italy
Keywords: Biaryls, metal-free, cross-coupling, diels-alder, annulation, oxidative coupling.
Abstract: Biaryls are a key structural motif in compounds with various applications, ranging from pharmaceuticals to material science, including ligands for organic synthesis. Given the growing concern about the use of transition metals in organic synthesis in terms of reaction condition mildness, substituents tolerance, reagents costs and toxicity, and purification of the products from metal traces, several alternatives have been developed to overcome the limitations of metal-catalyzed biaryls synthesis. Herein, we review the transition metal-free approaches to biaryls, which can be divided into metal-free crosscoupling of aromatics and metal-free benzannulation of aryl-substituted chains, as both fields have shown an impressive growth in recent years.
Export Options
About this article
Cite this article as:
Piazzolla Francesca *, Colognese Francesco and Temperini Andrea , Transition Metal-free Approaches to Biaryls, Current Organic Chemistry 2018; 22 (26) . https://dx.doi.org/10.2174/1385272822666181029114732
DOI https://dx.doi.org/10.2174/1385272822666181029114732 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements