Abstract
Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimers disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates such as huperzine A. In this review, a listing is presented of natural product inhibitors, both alkaloid and nonalkaloid in origin. These have been isolated from plant, animal and microbial sources. Details of current testing methods on cholinesterases are given, including solution assays and screening techniques by TLC and HPLC.
Keywords: TLC Assays, HPLC Assay, Radiometric Method, AChE activity, Physostigmine, Huperzine A, Amaryllidaceae, Xanthone inhibitors
Current Organic Chemistry
Title: Natural Product Inhibitors of Acetylcholinesterase
Volume: 10 Issue: 8
Author(s): K. Hostettmann, A. Borloz, A. Urbain and A. Marston
Affiliation:
Keywords: TLC Assays, HPLC Assay, Radiometric Method, AChE activity, Physostigmine, Huperzine A, Amaryllidaceae, Xanthone inhibitors
Abstract: Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimers disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates such as huperzine A. In this review, a listing is presented of natural product inhibitors, both alkaloid and nonalkaloid in origin. These have been isolated from plant, animal and microbial sources. Details of current testing methods on cholinesterases are given, including solution assays and screening techniques by TLC and HPLC.
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Cite this article as:
Hostettmann K., Borloz A., Urbain A. and Marston A., Natural Product Inhibitors of Acetylcholinesterase, Current Organic Chemistry 2006; 10 (8) . https://dx.doi.org/10.2174/138527206776894410
DOI https://dx.doi.org/10.2174/138527206776894410 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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