摘要
结肠直肠癌是一组异质性疾病，由不同基因组的改变和表观基因组的改变累计而引起，受肿瘤 - 宿主相互作用的影响，导致肿瘤细胞生长和糖酵解失衡。 该综述总结了最近的发现，糖酵解途径失调中涉及多种信号分子和下游基因。 本文进一步讨论了失调的糖酵解途径在结肠直肠癌患者中常见的肿瘤发生，进展和伴随的全身免疫抑制中的作用。 此外，讨论了结直肠癌细胞和T细胞，特别是CD8 + T细胞之间的关系，同时全面定义了癌细胞增殖中代谢途径调节的不同方面。 此外，本研究阐述了结直肠癌的代谢，特别是关键的代谢调节剂以及调节因子，糖酵解酶和肿瘤细胞诱导的葡萄糖剥夺以及它们如何抑制T细胞糖酵解和免疫原性功能。 另外，描述了对T细胞功能，分化和激活不可或缺的代谢途径。 靶向这些途径的选择性代谢抑制剂或免疫调节剂在临床上可用于增加结肠直肠癌治疗的效应T细胞应答。 然而，需要使用癌症患者个体化方法和与其他治疗剂的组合策略来鉴定特异性抗原以有效靶向肿瘤代谢途径。
关键词: 结肠直肠癌，葡萄糖代谢，T细胞，免疫微环境，治疗，基因组改变。
图形摘要
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