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Abstract
More than 90% of malignant tumors arising in humans are of epithelial origin. The loss of epithelial morphology and the acquisition of mesenchymal characteristics are important early events in tumor progression. This type of morphological transformation is termed an epithelial-mesenchymal transition. These transitions occur normally during embryonic development, as well as pathologically during tumor progression. This review will encapsulate our understanding of the role that epithelial-mesenchymal transitions play during tumor progression and metastasis, and we also summarize recent results describing the roles played by such genes as E-cadherin, Snail, and TGFβ in regulating epithelial-mesenchymal transitions and metastasis.
Keywords: epithelial-mesenchymal, e-cadherin, snail, tgf
Current Genomics
Title: Epithelial-Mesenchymal Transitions and Cancer
Volume: 3 Issue: 4
Author(s): Ethan A. Carver and Thomas Gridley
Affiliation:
Keywords: epithelial-mesenchymal, e-cadherin, snail, tgf
Abstract: More than 90% of malignant tumors arising in humans are of epithelial origin. The loss of epithelial morphology and the acquisition of mesenchymal characteristics are important early events in tumor progression. This type of morphological transformation is termed an epithelial-mesenchymal transition. These transitions occur normally during embryonic development, as well as pathologically during tumor progression. This review will encapsulate our understanding of the role that epithelial-mesenchymal transitions play during tumor progression and metastasis, and we also summarize recent results describing the roles played by such genes as E-cadherin, Snail, and TGFβ in regulating epithelial-mesenchymal transitions and metastasis.
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Cite this article as:
Carver A. Ethan and Gridley Thomas, Epithelial-Mesenchymal Transitions and Cancer, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350426
DOI https://dx.doi.org/10.2174/1389202023350426 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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