![conference banner](/images/conference-banner.jpeg)
Abstract
In Drosophila, Sprouty was originally identified as an antagonist of tracheal branching and shown to be a general inhibitor of receptor tyrosine kinase. Recently, four mammalian homologues have been isolated. All Sprouty proteins exhibit a unique, highly conserved, cysteinerich C-terminal domain. Genetic and biochemical data indicate that Sprouty proteins antagonize receptor tyrosine kinase signaling through specific inhibition of the Ras / Raf / MAP Kinase pathway by preventing Ras activation. Expression of sprouty genes is regulated by FGF in a negative autoregulatory loop and is localized to known domains of FGF signaling in the developing embryo. Overexpression studies suggest that vertebrate sprouty genes may be important regulators of several developmental processes. In particular, sprouty may play a role during the branching morphogenesis involved in angiogenesis, or the formation of the lung and the kidney, but also during gastrulation or limb formation.
Keywords: sprouty protein, receptor tyrosine kinase, sprouty gene
Current Genomics
Title: Sprouty Proteins, A New Family of Receptor Tyrosine Kinase Inhibitors
Volume: 3 Issue: 4
Author(s): Isabelle Gross and Jonathan D. Licht
Affiliation:
Keywords: sprouty protein, receptor tyrosine kinase, sprouty gene
Abstract: In Drosophila, Sprouty was originally identified as an antagonist of tracheal branching and shown to be a general inhibitor of receptor tyrosine kinase. Recently, four mammalian homologues have been isolated. All Sprouty proteins exhibit a unique, highly conserved, cysteinerich C-terminal domain. Genetic and biochemical data indicate that Sprouty proteins antagonize receptor tyrosine kinase signaling through specific inhibition of the Ras / Raf / MAP Kinase pathway by preventing Ras activation. Expression of sprouty genes is regulated by FGF in a negative autoregulatory loop and is localized to known domains of FGF signaling in the developing embryo. Overexpression studies suggest that vertebrate sprouty genes may be important regulators of several developmental processes. In particular, sprouty may play a role during the branching morphogenesis involved in angiogenesis, or the formation of the lung and the kidney, but also during gastrulation or limb formation.
Export Options
About this article
Cite this article as:
Gross Isabelle and Licht D. Jonathan, Sprouty Proteins, A New Family of Receptor Tyrosine Kinase Inhibitors, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350408
DOI https://dx.doi.org/10.2174/1389202023350408 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
Genomic Insights into Oncology: Harnessing Machine Learning for Breakthroughs in Cancer Genomics.
This special issue aims to explore the cutting-edge intersection of genomics and oncology, with a strong emphasis on original data and experimental validation. While maintaining the focus on how machine learning and advanced data analysis techniques are revolutionizing our understanding and treatment of cancer, this issue will prioritize contributions that ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Perioperative Management of Intracranial Aneurysm and Subarachnoid Hemorrhage
Current Pharmaceutical Design Aging and Systemic Lupus Erythematosus - Immunosenescence and Beyond
Current Aging Science Diagnostic and Prognostic Potential of the Macrophage Specific Receptor CD163 in Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Immunosuppressive Therapies in Solid Organ Transplantation
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Suppression of Virulence of Porphyromonas gingivalis by Potent Inhibitors Specific for Gingipains
Current Protein & Peptide Science The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study
Current Pharmaceutical Design Metabolic Effects of Resveratrol in Mammals - a Link Between Improved Insulin Action and Aging
Current Aging Science Editorial The Role of Mesenchymal Stem Cells in Bone Regeneration: Underlying Mechanisms and Systemic Regulatory Factors
Current Stem Cell Research & Therapy Coronary Atherosclerosis The Implications of Being a Woman
Current Hypertension Reviews The Role of Inflammation and Allergy in Acute Coronary Syndromes
Inflammation & Allergy - Drug Targets (Discontinued) Leptin and Vascular Smooth Muscle
Current Vascular Pharmacology The Dynamics of the Hypothalamic-Pituitary-Ovarian Axis, ReproductivePerformance and Sexuality Following Bariatric Surgery
Current Women`s Health Reviews Recent Developments in the Mechanism of Anticancer Agents Based on Electron Transfer, Reactive Oxygen Species and Oxidative Stress
Anti-Cancer Agents in Medicinal Chemistry Critical Illness in Obstetric Patients: Introduction and Epidemiology
Current Women`s Health Reviews Research Progress in Competitive Purine Antagonists
Current Medicinal Chemistry Benefits of Chinese Medicine Among Patients with Diabetic Foot: An Expert Review from Clinical Studies
Current Vascular Pharmacology Targeting of Antioxidant and Anti-Thrombotic Drugs to Endothelial Cell Adhesion Molecules
Current Pharmaceutical Design Development and Potential Utility of Dual and Triple NK Receptor Antagonists
Current Topics in Medicinal Chemistry HDL Therapy: Two Kinds of Right?
Current Pharmaceutical Design Patent Selections:
Recent Patents on Cardiovascular Drug Discovery