Title:Current Clinical Application and Response Prediction Biomarkers of PARP Inhibitors
Volume: 16
Issue: 2
Author(s): Wei-Hua Shao, Lei-Yun Wang and Ji-Ye Yin*
Affiliation:
- Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008,China
Keywords:
PARP inhibitor, DNA repair, pharmacogenetics, drug response, cancer, veliparib, talazoparib.
Abstract: Recently, novel drugs that inhibit the enzyme poly (ADP-ribose) polymerase
(PARP) based on the concept of synthetic lethality are used for cancer treatment. Three
PARP inhibitors (olaparib, rucaparib and niraparib) are approved for the treatment of recurrent
ovarian cancer in the US or Europe, while another two (veliparib and talazoparib)
showed promising anti-cancer activity. This review aims to summarize the current status
of clinical trials on PARP inhibitors and then discusses studies aimed to identify biomarkers
for predicting the efficacy of PARP inhibitors.
