摘要
糖尿病肾病是肾功能衰竭的主要原因之一,占所有病例的44%。尽管糖尿病肾病的死亡率很高,但有针对性和有效的治疗方法。T还在逃避。确定遗传决定因素并了解其在疾病进展中的作用,对于开发诊断工具和有效治疗至关重要。果蝇龙舌兰是一种基因可操作的模型生物,目前正被用于了解人类多种疾病的遗传基础。果蝇的肾脏系统发育得很好,并且有共同的保守性。人类的发育和功能过程。除肾系统相似外,1型糖尿病和2型糖尿病在果蝇中的诱导机制与人类相似。蒂伊综述了目前糖尿病肾病的治疗方法,并探讨了果蝇肾系统作为糖尿病肾病药物靶点识别模型的潜力。筛选潜在药物的有效性。
关键词: 糖尿病肾病,果蝇,足细胞,肾细胞,果蝇肾器官,治疗药物。
Current Drug Targets
Title:Drosophila Renal Organ as a Model for Identification of Targets and Screening of Potential Therapeutic Agents for Diabetic Nephropathy
Volume: 19 Issue: 16
关键词: 糖尿病肾病,果蝇,足细胞,肾细胞,果蝇肾器官,治疗药物。
摘要: Diabetic nephropathy is one of the major causes of kidney failure, accounting for ~44% of all cases. In spite of the significant mortality rate of diabetic nephropathy, specific and effective treatment is still eluding. Identification of genetic determinants and understanding their role in the progression of disease are essential for developing diagnostic tools and effective therapy. Drosophila melanogaster is a genetically tractable model organism and is being used for understanding the genetic basis of several human diseases. Drosophila has a well developed renal system and shares conserved developmental and functional processes with humans. Apart from similarities in renal system, type 1 and type 2 diabetes can be induced in Drosophila following mechanisms similar to those in human. This review discusses the current therapies available for diabetic nephropathy and examines the potential of Drosophila renal system as a model for identifying drug targets for diabetic nephropathy and screening of the potential drugs for their efficacy.
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Drosophila Renal Organ as a Model for Identification of Targets and Screening of Potential Therapeutic Agents for Diabetic Nephropathy, Current Drug Targets 2018; 19 (16) . https://dx.doi.org/10.2174/1389450119666180808114533
DOI https://dx.doi.org/10.2174/1389450119666180808114533 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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