摘要
内脏脂肪素是脂肪组织分泌的重要脂肪因子之一,随着体重指数(BMI)的增加,肥胖人群中的内脏脂肪素水平显著升高,肥胖时脂肪细胞大量增生和肥大,并分泌大量的脂肪细胞因子,包括内脏脂肪素。内脏脂肪素也是烟酰胺磷酸核糖基转移酶的一种酶,是影响机体代谢稳态的重要脂肪因子之一,它以细胞外和细胞内两种形式存在,具有多种作用。从体外、体内和临床研究中获得的直接和间接证据表明,内脏脂肪素调节了许多细胞类型中与肥胖和代谢综合征相关的病理生理活动,包括炎症、血管生成、NAD单核苷酸的合成和抗凋亡蛋白的上调。它与许多肥胖相关的改变和代谢紊乱有关,如糖尿病、心血管并发症和某些类型的癌症。本文就内脏脂肪素在糖尿病中的作用提出了新的假说,提示了近年来有关内脏脂肪素在肥胖和慢性高糖循环中的病理生理作用的研究进展。高浓度的内脏脂肪素能吸引免疫细胞,并在脂肪细胞中产生慢性炎症,并在许多组织中引起胰岛素抵抗,并在后期引起胰腺β细胞功能障碍,并有望成为治疗糖尿病及相关代谢综合征的重要分子药物。
关键词: 内脏脂肪素,代谢紊乱,炎症,高脂血症,糖尿病,脂肪因子,糖尿病。
Current Molecular Medicine
Title:Adipokine Visfatin’s Role in Pathogenesis of Diabesity and Related Metabolic Derangements
Volume: 18 Issue: 2
关键词: 内脏脂肪素,代谢紊乱,炎症,高脂血症,糖尿病,脂肪因子,糖尿病。
摘要: Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokines including visfatin. Visfatin, which also acts as an enzyme nicotinamide phosphoribosyl transferase, is one of the prominent adipokines that influence metabolic homeostasis in the body. Visfatin exists in two forms, extracellular and intracellular, and enacts a multitude of actions. The direct and indirect evidence gathered from in-vitro, in-vivo and clinical studies indicate that visfatin modulates obesity and metabolic syndrome-related pathophysiological activities including enhanced inflammation, angiogenesis, synthesis of NAD mononucleotide, and upregulation of antiapoptotic proteins in a number of cell types. It has been implicated in a number of obesity-related alterations and metabolic derangement such as diabetes, cardiovascular complications and some forms of cancers. In this review, the novel hypothesis about the role of visfatin in diabesity has been proposed which implies recent advances in studies about the pathophysiological roles of visfatin during obesity and chronic high glucose in the circulation. Visfatin at high concentration attracts immune cells and produces chronic inflammation in adipocytes. Additionally, it induces insulin resistance in many tissues and causes pancreatic beta cells dysfunction at later stages. Further, its potential as an important target to develop molecular medicine in diabesity and related metabolic syndrome has been highlighted.
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Cite this article as:
Adipokine Visfatin’s Role in Pathogenesis of Diabesity and Related Metabolic Derangements, Current Molecular Medicine 2018; 18 (2) . https://dx.doi.org/10.2174/1566524018666180705114131
DOI https://dx.doi.org/10.2174/1566524018666180705114131 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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