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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

The Relationship between Pharmacological Properties and Structure- Activity of Chrysin Derivatives

Author(s): Yang Li, Yan-peng Li, Jun He*, Ding Liu, Qi-zhi Zhang, Kang Li, Xing Zheng, Guo-Tao Tang, Yu Guo and Yunmei Liu*

Volume 19, Issue 7, 2019

Page: [555 - 568] Pages: 14

DOI: 10.2174/1389557518666180424094821

Price: $65


Chrysin is a natural product of a flavonoid compound. Chemically, chrysin consists of two phenyl rings (A and B) and a heterocyclic ring (C). Biologically, chrysin exerts many different physiological activities. In recent years, with the in-depth development for more active drugs, the synthesis and biological activities of chrysin derivatives have been well studied. Besides, structure-activity relationship of chrysin revealed that the chemical construction meets the critical chemical structural necessities of flavonoids for numerous pharmacological activities. It is generally believed that modified chrysin could be more potent than unmodified chrysin. Different modification in the rings of chrysin could possess various degrees of biological activities. This review aims to summarize the mechanism for the activities of chrysin and its derivatives in different rings. We also explored the relationship between biological function and structure-activity of substituted chrysin derivatives with different functional groups. The influence of chrysin derivatives on the proliferation and apoptosis of cancer cells is also investigated. Development of novel drugs based on the biological functions of chrysin could better improve clinical outcomes of affected population, especially for tumor patients and diabetic patients.

Keywords: Chrysin, chrysin derivatives, synthesis, biological activities, structure-activity relationships, drug target.

Graphical Abstract
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