摘要
背景:糖结合蛋白广泛分布于人类体内,在生物过程中起着至关重要的作用.他们在炎症和免疫反应中的参与使其变得越来越像甘氨酸结合蛋白可能是有价值的治疗靶点。目的:本综述旨在提供抗体临床进展的最新资料。作为潜在靶点的糖结合蛋白。 结果与结论:目前已开发出多种针对不同疾病的治疗性抗体,包括CD22、CD33、DEC-205和CD62P。临床投资免疫测定显示了一种抗CD 22抗体药物结合治疗的益处,并得到了监管机构的批准。这些抗体的临床研究进展为治疗多种疾病(包括炎症、自身免疫性疾病和血液恶性肿瘤)提供了良好的治疗靶点。
关键词: 甘氨酸结合蛋白,凝集素,抗体,临床发育,炎症,自身免疫性疾病,血液学 malignance恶意,有害
Current Drug Targets
Title:Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins
Volume: 19 Issue: 13
关键词: 甘氨酸结合蛋白,凝集素,抗体,临床发育,炎症,自身免疫性疾病,血液学 malignance恶意,有害
摘要: Background: Glycan-binding proteins are widely distributed in human and play an essential role in biological processes. Their involvements in inflammatory and immune responses make it increasingly likely that the glycan-binding proteins may represent valuable therapeutic targets.
Objective: The current review aims to provide information on recent advancements in clinical developments of antibodies against glycan-binding proteins as potential targets.
Results and Conclusion: There are several therapeutic antibodies being developed targeting glycanbinding proteins, including CD22, CD33, DEC-205, and CD62P, for different diseases. The clinical investigations demonstrated benefits of treatments with one antibody-drug conjugate against CD22 being approved by the regulatory agencies. The recent progresses in clinical developments of these antibodies have provided great promises in therapeutic targeting of more glycan-binding proteins for treating multiple diseases, including inflammation, autoimmune diseases, and hematological malignancies.
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Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins, Current Drug Targets 2018; 19 (13) . https://dx.doi.org/10.2174/1389450119666180308144313
DOI https://dx.doi.org/10.2174/1389450119666180308144313 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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