摘要
背景:AAU(急性前葡萄膜炎)是最常见的实体的葡萄膜炎的特点是急性视力丧失和暴力眼痛。IL-33和IL-1RacP发现先天免疫系统中起着至关重要的作用。目的:在目前的研究中,我们调查了IL33协会和AAU IL1RAP基因。方法:共有549名AAU患者和1080个不相关的人被招募为健康对照组。十个单核苷酸多态性(snp)基因分型使用Sequenom大规模阵列技术。结果:我们的研究结果表明,IL1RAP-rs3773978与AAU显著相关,可作为遗传标记在中国AAU患者风险。大大增加一个等位基因的频率和AA的纯合性IL1RAP-rs3773978 AAU患者的观察与控制(p = 0.001,pc = 0.01,= 1.282,95%可信区间1.106到1.487;p = 0.0003、pc = 0.003 = 1.647,95%可信区间1.255到2.163)。进一步分层分析表明,遗传相关性可能不同,这取决于HLA-B27状态(强直性脊柱炎)状态,攻击时间和一侧的地位。结论:我们的研究结果提供了新的见解,提高当前的葡萄膜炎遗传学知识通过展示IL1RAP的具体功能角色和其他il - 1家族基因在葡萄膜炎。
关键词: IL33 IL1RAP
Current Molecular Medicine
Title:Association of IL33 and IL1RAP Polymorphisms With Acute Anterior Uveitis
Volume: 17 Issue: 7
关键词: IL33 IL1RAP
摘要: Background: AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 and IL-1RacP have been found to play crucial roles in the innate immune system.
Objective: In the present study, we investigated the association of IL33 and IL1RAP genes with AAU.
Method: A total of 549 AAU patients and 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) were genotyped using Sequenom Mass ARRAY technology.
Results: Our findings demonstrated that IL1RAP-rs3773978 significantly associated with AAU and could serve as a genetic risk marker in Chinese AAU patients. A significantly increased frequency of the A allele and AA homozygosity of IL1RAP-rs3773978 was observed in AAU patients compared with that in controls (p=0.001, pc=0.01, OR=1.282, 95% CI 1.106 to 1.487; p=0.0003, pc=0.003, OR=1.647, 95% CI 1.255 to 2.163, respectively). Further stratification analyses showed that the genetic correlation may differ depending on HLA-B27 status, AS (ankylosing spondylitis) status, attack times and laterality status.
Conclusion: Our findings provide new insights that enhance the current knowledge of uveitis genetics by demonstrating the specific functional roles of IL1RAP and other IL-1 family genes in uveitis.
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Cite this article as:
Association of IL33 and IL1RAP Polymorphisms With Acute Anterior Uveitis, Current Molecular Medicine 2017; 17 (7) . https://dx.doi.org/10.2174/1566524018666180207154938
DOI https://dx.doi.org/10.2174/1566524018666180207154938 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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