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摘要
背景:通过专门的研究,已经作出了巨大的努力,以发展稳健,护理点,便携式,成本效益,敏感和具体的微生物检测分析方法。乙离子感应和纳米技术提供了新的策略,设计最先进的设备和检测格式,增强敏感性和所有其他需要的特点。单克隆抗体作为生物识别元件使用了几十年。然而,最近的研究表明,适配体在许多应用中优于单克隆抗体。许多研究小组都有苏。利用适体作为捕获探针,研制微生物检测生物传感器。 目的:这篇综述文章的主要目的是向读者介绍在适配体和aptasensor检测和识别方面的最新进展。N种微生物制剂。 结果:我们对适配体和适体传感器目前进展的相关信息显示,在过去的二十年中,我们成功地尝试了一些选择方法。以及它们在细菌检测中的应用。 结论:适配体和适配体虽然尚处于起步阶段,但在快速、敏感、护理和成本效益高的微生物检测方面有着广阔的应用前景。
关键词: SELEX,适体,微生物识别元件,先进的微生物检测,生物传感器。
Current Drug Targets
Title:Aptamers and Aptasensors as Novel Approach for Microbial Detection and Identification: An Appraisal
Volume: 19 Issue: 13
关键词: SELEX,适体,微生物识别元件,先进的微生物检测,生物传感器。
摘要: Background: Tremendous efforts through dedicated research have been made for the development of robust, point of care, portable, cost effective, sensitive and specific assays of microbial detection. Biosensing and nanotechnology offer novel strategies of designing state of the art devices and assay formats with enhanced sensitivity and all other desired features. Monoclonal antibodies have been in use as biorecognition elements for decades. However, recent studies have demonstrated superiority of aptamers to monoclonal antibodies in a number of applications. Many of the research groups have successfully utilized aptamers as capture probes in developing biosensors for microbial detection.
Objectives: The main objective of this review article is to present the reader with an overview of the recent advances made in the field of aptamers and aptasensors for the detection and identification of microbial agents.
Results: Our search for relevant information on current advances on aptamers and aptasensors has revealed that a number of successful attempts have been made in the last two decades for the selection of aptamers as well as their applications in aptasensors for microbial detection.
Conclusion: Aptamers and aptasensors, although in their infancy, may find promising application in rapid, sensitive, point of care and cost effective microbial detection.
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Cite this article as:
Aptamers and Aptasensors as Novel Approach for Microbial Detection and Identification: An Appraisal, Current Drug Targets 2018; 19 (13) . https://dx.doi.org/10.2174/1389450119666180105115429
DOI https://dx.doi.org/10.2174/1389450119666180105115429 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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