摘要
背景:肝脏是所有脊椎动物中最大、最重要的器官。它具有多种主要功能,如解毒、代谢、蛋白质合成、排泄等。肝cElls分为实质细胞和非实质细胞.肝细胞、枯否细胞、肝星状细胞、窦内皮细胞等均存在于不同受体的肝脏。RS存在于其表面,可通过与不同配体结合,用于肝脏靶向。 目的:本文综述了药物、植物、金属等多种因素引起肝毒性、天然肝保护剂的研究进展。S和肝脏靶向通过新的配方方法。 结论:世界各地有数以百万计的人受到严重的肝脏疾病的影响,尽管付出了许多努力,但这些疾病很难治疗。肝毒性是造成肝损伤的主要原因之一。哪些药物继续从市场上销售。本文着重介绍了各种植物化学物质作为肝保护剂的潜力以及对阿奇提出的各种策略。Ve肝靶向,包括被动累积治疗药物给药系统和主动靶向通过表面修饰颗粒制剂与特定配体。
关键词: 肝毒性,肝保护剂,活性靶向,药物传递系统,非实质细胞,肝细胞。
Current Drug Targets
Title:Significance of Hepatoprotective Liver Specific Targeted Drug Delivery: A Review on Novel Herbal and Formulation Approaches in the Management of Hepatotoxicity
Volume: 19 Issue: 13
关键词: 肝毒性,肝保护剂,活性靶向,药物传递系统,非实质细胞,肝细胞。
摘要: Background: The liver is the largest and vital organ present in all vertebrates. It performs various major functions such as detoxification, metabolism, protein synthesis, excretion and so on. Liver cells are divided into parenchymal cells and non-parenchymal cells. Hepatocytes, Kupffer cells, hepatic stellate cells and sinusoidal endothelial cells, etc. are found in liver having different receptors present on their surface which can be used for liver targeting by binding to different ligands.
Objective: In this review, we focused on various factors such as drugs, plants; metals and so on are reported in literature to be responsible for causing hepatotoxicity, natural hepatoprotective agents and liver targeting via novel formulation approaches.
Conclusion: All over the world, millions of people are affected by serious liver disorders which are very difficult to treat despite of many efforts. Hepatotoxicity is one of the major reasons due to which drugs continue to be taken off from the market. This review highlights the potential of various phytochemicals as hepatoprotective agents and various strategies which have been proposed to achieve liver targeting, including passive accumulation of therapeutic drug delivery system and active targeting by surface modifications of particulate formulation with specific ligands.
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Significance of Hepatoprotective Liver Specific Targeted Drug Delivery: A Review on Novel Herbal and Formulation Approaches in the Management of Hepatotoxicity, Current Drug Targets 2018; 19 (13) . https://dx.doi.org/10.2174/1389450119666180104113601
DOI https://dx.doi.org/10.2174/1389450119666180104113601 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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