摘要
背景:雄激素受体(AR)的适应性上调是激素敏感型前列腺癌(CRPC)向去势耐药型前列腺癌(CRPC)发展过程中最常见的事件。AR信号域达到了新的AR信号导向治疗的主要目标,如阿弗他酮和恩扎鲁塔胺在CRPC患者中的应用。 目的:本文综述了AR靶向治疗的一般机制,重点讨论了AR拷贝数(CN)的作用。我们报道了AR CN的方法和临床应用。组织和液体活检的评估,从而获得关于其作为预测和预后生物标记物的作用的完整信息。 结论:由于肿瘤异质性,CRPC患者的预后变化很大。ARCN对CRPC治疗WIT患者的选择和肿瘤监测有一定的帮助。H.新的抗癌治疗方法,如阿弗他酮和恩扎鲁塔胺。进一步研究AR、CN对这些药物的影响及其与其他预后或预测临床事实的潜在结合。在协调临床试验设计的背景下,ORS是必要的。
关键词: 雄激素受体,AR拷贝数,生物标志物,CRPC,前列腺癌,预后。
Current Cancer Drug Targets
Title:AR Copy Number and AR Signaling-directed Therapies in Castrationresistant Prostate Cancer
Volume: 18 Issue: 9
关键词: 雄激素受体,AR拷贝数,生物标志物,CRPC,前列腺癌,预后。
摘要: Background: Adaptive upregulation of Androgen Receptor (AR) is the most common event involved in the progression from hormone sensitive to Castration-Resistant Prostate Cancer (CRPC). AR signaling remains the main target of new AR signalling-directed therapies such as abiraterone and enzalutamide in CRPC patients.
Objective: In this review, we discuss general mechanisms of resistance to AR-targeted therapies, with a focus on the role of AR Copy Number (CN). We reported methods and clinical applications of AR CN evaluation in tissue and liquid biopsy, thus to have a complete information regarding its role as predictive and prognostic biomarker.
Conclusion: Outcomes of CRPC patients are reported to be highly variable as the consequence of tumor heterogeneity. AR CN could contribute to patient selection and tumor monitoring in CRPC treated with new anti-cancer treatment as abiraterone and enzalutamide. Further studies to investigate AR CN effect to these agents and its potential combination with other prognostic or predictive clinical factors are necessary in the context of harmonized clinical trial design.
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AR Copy Number and AR Signaling-directed Therapies in Castrationresistant Prostate Cancer, Current Cancer Drug Targets 2018; 18 (9) . https://dx.doi.org/10.2174/1568009617666171122145852
DOI https://dx.doi.org/10.2174/1568009617666171122145852 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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