摘要
背景:科学报道表明,应激与机体众多的病理改变有关,这些病理改变可引起多种疾病,对个体产生明显的负面影响,包括胃溃疡、肝脏病理和神经行为改变,许多与应激有关的疾病的共同病机都涉及氧化损伤,因此维生素e等抗氧化剂的应用是一种合理的治疗方法,但关于补充抗氧化剂的证据并不一致。 目的:总结文献报道生育酚和生育酚对应激所致各种病理变化的影响。 结果与结论:本综述将揭示应激动物模型中肠内补充维生素e的科学依据,这些模型模拟了危重病人在临床环境中所承受的压力和个体的心理应激,并对肠内喂维生素e减少应激性病理改变的阳性结果进行了讨论。研究结果包括其减轻应激性胃溃疡的能力、肝酶活性的升高和运动功能的改善。本文还讨论了托科三烯醇和生育酚的作用不仅与其减轻氧化应激的能力有关,而且对其他机制的作用也进行了讨论。
关键词: 生育酚,妥曲诺,应激,胃溃疡,激素,脂质过氧化,主要器官。
Current Drug Targets
Title:Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress
Volume: 19 Issue: 12
关键词: 生育酚,妥曲诺,应激,胃溃疡,激素,脂质过氧化,主要器官。
摘要: Background: Scientific reports had shown that stress is related to numerous pathological changes in the body. These pathological changes can bring about numerous diseases and can significantly cause negative effects in an individual. These include gastric ulcer, liver pathology and neurobehavioral changes. A common pathogenesis in many diseases related to stress involves oxidative damage. Therefore, the administration of antioxidants such as vitamin E is a reasonable therapeutic approach. However, there is conflicting evidence about antioxidant supplementation.
Objective: The aim of this work was to summarize documented reports on the effects of tocopherol and tocotrienol on various pathological changes induced by stress.
Results and Conclusion: This review will reveal the scientific evidence of enteral supplementation of vitamin E in the forms of tocotrienol and tocopherol in animal models of stress. These models mimic the stress endured by critically ill patients in a clinical setting and psychological stress in individuals. Positive outcomes from enteral feeding of vitamin E in reducing the occurrence of stress-induced pathological changes are discussed in this review. These positive findings include their ability to reduced stress-induced gastric ulcers, elevated liver enzymes and improved locomotors activity. Evidences showing tocotrienol and tocopherol effects are not just related to its ability to reduce oxidative stress but also acting on other mechanism, are discussed.
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Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress, Current Drug Targets 2018; 19 (12) . https://dx.doi.org/10.2174/1389450118666171122130338
DOI https://dx.doi.org/10.2174/1389450118666171122130338 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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