Abstract
Background & Objective: Our research objective was to design, develop, optimize and characterize Granisetron HCl transdermal gel in order to minimize side effects associated with oral delivery.
Method: A statistical design was practically applied for further optimization and preparation of transfersomal gel using Box-Behnken methodology at three levels. The selected independent and dependent variables were Lipoid, surfactant and sonication time and encapsulation efficiency, size and flux correspondingly.
Result: The optimized formulation (GTV-16) morphology, shape, size, potential, encapsulation capacity and flux (using Franz-diffusion cell assembly via animal skin barricade medium) were determined. Then, GTV-16 incorporated into gel and during evaluation nano-transformal gel has good particle size of 127.7±1.08 nm, better entrapment efficiency of 83.0 ± 3.22 % and flux of 20.0 ± 1.88µgcm-2/h.
Conclusion: The results demonstrated that Granisetron Hydrochloride loaded nano-gel was significantly superior with 8.5 fold enhancement in bioavailability as compared with drug solution.
Keywords: Box-Behnken, ex-vivo, gel, granisetron-hydrochloride, transdermal flux, transfersomes.
Pharmaceutical Nanotechnology
Title:Design, Optimization and Characterization of Granisetron HCl Loaded Nano-gel for Transdermal Delivery
Volume: 5 Issue: 4
Author(s): Geeta Aggarwal, Vikash Kumar*Hema Chaudhary
Affiliation:
- PDM University, PDM College of Pharmacy, B'garh,India
Keywords: Box-Behnken, ex-vivo, gel, granisetron-hydrochloride, transdermal flux, transfersomes.
Abstract: Background & Objective: Our research objective was to design, develop, optimize and characterize Granisetron HCl transdermal gel in order to minimize side effects associated with oral delivery.
Method: A statistical design was practically applied for further optimization and preparation of transfersomal gel using Box-Behnken methodology at three levels. The selected independent and dependent variables were Lipoid, surfactant and sonication time and encapsulation efficiency, size and flux correspondingly.
Result: The optimized formulation (GTV-16) morphology, shape, size, potential, encapsulation capacity and flux (using Franz-diffusion cell assembly via animal skin barricade medium) were determined. Then, GTV-16 incorporated into gel and during evaluation nano-transformal gel has good particle size of 127.7±1.08 nm, better entrapment efficiency of 83.0 ± 3.22 % and flux of 20.0 ± 1.88µgcm-2/h.
Conclusion: The results demonstrated that Granisetron Hydrochloride loaded nano-gel was significantly superior with 8.5 fold enhancement in bioavailability as compared with drug solution.
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Cite this article as:
Aggarwal Geeta , Kumar Vikash *, Chaudhary Hema , Design, Optimization and Characterization of Granisetron HCl Loaded Nano-gel for Transdermal Delivery, Pharmaceutical Nanotechnology 2017; 5 (4) . https://dx.doi.org/10.2174/2211738505666170915151118
DOI https://dx.doi.org/10.2174/2211738505666170915151118 |
Print ISSN 2211-7385 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-7393 |
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Polymeric nanocarriers in drug delivery
Polymeric nanocarriers play a crucial role in drug delivery due to their versatility, and unique properties for targeting and modifying drug release. Their ability to enhance therapeutic outcomes, reduce side effects, and enable the delivery of drugs in a more targeted and controlled manner made them popular in the last ...read more
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