Design, Optimization and Characterization of Granisetron HCl Loaded Nano-gel for Transdermal Delivery

Title:Design, Optimization and Characterization of Granisetron HCl Loaded Nano-gel for Transdermal Delivery

Volume: 5 Issue: 4

Author(s): Geeta Aggarwal, Vikash Kumar*Hema Chaudhary

Affiliation:

• PDM University, PDM College of Pharmacy, B'garh,India

Keywords: Box-Behnken, ex-vivo, gel, granisetron-hydrochloride, transdermal flux, transfersomes.

Abstract: Background & Objective: Our research objective was to design, develop, optimize and characterize Granisetron HCl transdermal gel in order to minimize side effects associated with oral delivery.

Method: A statistical design was practically applied for further optimization and preparation of transfersomal gel using Box-Behnken methodology at three levels. The selected independent and dependent variables were Lipoid, surfactant and sonication time and encapsulation efficiency, size and flux correspondingly.

Result: The optimized formulation (GTV-16) morphology, shape, size, potential, encapsulation capacity and flux (using Franz-diffusion cell assembly via animal skin barricade medium) were determined. Then, GTV-16 incorporated into gel and during evaluation nano-transformal gel has good particle size of 127.7±1.08 nm, better entrapment efficiency of 83.0 ± 3.22 % and flux of 20.0 ± 1.88µgcm-2/h.

Conclusion: The results demonstrated that Granisetron Hydrochloride loaded nano-gel was significantly superior with 8.5 fold enhancement in bioavailability as compared with drug solution.

Cite this article as:

Aggarwal Geeta , Kumar Vikash *, Chaudhary Hema , Design, Optimization and Characterization of Granisetron HCl Loaded Nano-gel for Transdermal Delivery, Pharmaceutical Nanotechnology 2017; 5 (4) . https://dx.doi.org/10.2174/2211738505666170915151118