Meet the Guest Editor

Gerard      Rosse

doi:10.2174/138620703771981278

Abstract

Gerard Rosse grew up in Chatillon, a small town located in the French speaking region of Switzerland. He received his B.S. and Ph.D. in Chemistry from the University of Basle, Switzerland. His undergraduate studies, completed in 1991, encompassed a Diploma work on natural products total synthesis under the supervision of Prof. Christoph Tamm. Dr. Rosses doctoral thesis on the design, synthesis and biological characterization of multisubstrate-complex analogues as inhibitors of the EGF-Receptor protein tyrosine kinase was completed in 1995 with Prof. Urs Sequin and in collaboration with Dr. Heinz Fretz and Dr. Peter Traxler from Novartis (formerly Ciba-Geigy), Basle, Switzerland. He then studied as a post-doctoral fellow at Stanford University under Prof. John Griffin and working on combinatorial libraries of vancomycin derivatives. In 1997, Dr. Rosse moved back to Basle, where he was hired as a research chemist by F. Hoffmann-La Roche Inc. While at Roche, he worked within the combinatorial chemistry group of Dr. Lutz Weber on the synthesis of libraries small molecules. He also was involved in a variety of other projects including the development of antiinfective agents, high throughput NMR analysis and the investigation and application of bead-based methods for deorphaning genomically derived proteases. Since 1999, Dr. Rossé is working with Aventis, at the Aventis Combinatorial Technologies Center (ACTC), Tucson, Arizona. He is a Chemistry Group Leader and is leading the ACTC purification group as well. The research interests of Dr. Rossé include many aspects of drug discovery, with special emphasis on understanding the chemical biology of GPCRs and Kinases by designing and synthesizing focused libraries. He is also involved in the optimization of hits to leads, in the development of information technologies and instrumentations for parallel synthesis and purification. He has published many articles and patents. Dr. Rosse currently lives with his wife, Frederique, and two daughters, Alyssa and Noanne, in Oro Valley, AZ.

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