Abstract
Objective: A simple and rapid method for the measurement of paracetamol in oral pharmaceutical preparations by a commercial glucometer was proposed.
Methods: The established method was successfully applied to the determination of paracetamol in oral solid preparations, and exhibited the excellent capability of resisting interference from co-existing excipients. The commercial disposable test strips of hand-held glucometer showed high consistency of electrocatalytic activity toward the oxidation of paracetamol between each other.
Results: The linear range was from 0.2 mg/ml to 3.5 mg/ml with the detection limit of less than 0.2 mg/ml. The results demonstrated that the test strips can be used as a sensitive, selective and low-cost sensor for amperometric determination of paracetamol in oral solid dosage forms.
Conclusion: The unique application of household glucometer presented a convenient home-use tool for the paediatric subministration of the home medicine in common use.
Keywords: Paracetamol, Glucometer, Paediatric subministration, Oral solid dosage form, Amperometric determination, Electrochemical sensor.
Current Pharmaceutical Analysis
Title:Simple and Rapid Determination of Paracetamol in Oral Pharmaceutical Preparations by a Home-use Glucometer for Paediatric Subministration
Volume: 14 Issue: 4
Author(s): Ge Wang, Jing Zhu, Wei Wu*Wei Zhang*
Affiliation:
- Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004,China
- Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004,China
Keywords: Paracetamol, Glucometer, Paediatric subministration, Oral solid dosage form, Amperometric determination, Electrochemical sensor.
Abstract: Objective: A simple and rapid method for the measurement of paracetamol in oral pharmaceutical preparations by a commercial glucometer was proposed.
Methods: The established method was successfully applied to the determination of paracetamol in oral solid preparations, and exhibited the excellent capability of resisting interference from co-existing excipients. The commercial disposable test strips of hand-held glucometer showed high consistency of electrocatalytic activity toward the oxidation of paracetamol between each other.
Results: The linear range was from 0.2 mg/ml to 3.5 mg/ml with the detection limit of less than 0.2 mg/ml. The results demonstrated that the test strips can be used as a sensitive, selective and low-cost sensor for amperometric determination of paracetamol in oral solid dosage forms.
Conclusion: The unique application of household glucometer presented a convenient home-use tool for the paediatric subministration of the home medicine in common use.
Export Options
About this article
Cite this article as:
Wang Ge , Zhu Jing , Wu Wei *, Zhang Wei *, Simple and Rapid Determination of Paracetamol in Oral Pharmaceutical Preparations by a Home-use Glucometer for Paediatric Subministration, Current Pharmaceutical Analysis 2018; 14 (4) . https://dx.doi.org/10.2174/1573412913666170509155135
DOI https://dx.doi.org/10.2174/1573412913666170509155135 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Key Role of Canonical Wnt/β-catenin Signaling in Cartilage Chondrocytes
Current Drug Targets Identification of Novel Breast Cancer Genes based on Gene Expression Profiles and PPI Data
Current Proteomics The Role of Bax/Bcl-2 and Pro-Caspase Peptides in Hypoxia/Reperfusion-Dependent Regulation of MAPKERK: Discordant Proteomic Effect of MAPKp38
Protein & Peptide Letters Obesity and Body Fat Distribution as Predictors for Obstructive Sleep Apnea Syndrome
Current Respiratory Medicine Reviews Anti-atherosclerotic Effects of Spice-Derived Phytochemicals
Current Medicinal Chemistry Putative Involvement of Endocrine Disruptors in the Alzheimer's Disease Via the Insulin-Regulated Aminopeptidase/GLUT4 Pathway
Current Neuropharmacology Small Molecule Neurotrophin Receptor Ligands: Novel Strategies for Targeting Alzheimers Disease Mechanisms
Current Alzheimer Research Bidirectional Nature of Cardiovascular and Kidney Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Tetracyclines and Pulmonary Inflammation
Endocrine, Metabolic & Immune Disorders - Drug Targets Elaborate Chemical Sensors Based on Graphene/Conducting Polymer Hybrids
Current Organic Chemistry Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Twenty Years of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Time to Reevaluate their Toxicity
Current Medicinal Chemistry Recent Advances in Delivery Through the Blood-Brain Barrier
Current Topics in Medicinal Chemistry Structural Bioinformatic Approaches to the Discovery of New Antimycobacterial Drugs
Current Pharmaceutical Design Role of Estrogen Receptors and GPR30/GPER in Glucose Homeostasis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Adenocarcinoma of the Appendix in Elderly: Diagnostic Dilemma
New Emirates Medical Journal Ethnopharmacological and Phytopharmaceutical Evaluation of Prosopis cineraria: An Overview and Future Prospects
Current Drug Metabolism Polymorphism of Secretary PLA2G2A Gene Associated with Its Serum Level in Type2 Diabetes Mellitus Patients in Northern Iran
Endocrine, Metabolic & Immune Disorders - Drug Targets High-Density Lipoprotein-Raising Strategies: Update 2010
Current Pharmaceutical Design Integration of <sup>18</sup>FDG-PET Metabolic and Functional Connectomes in the Early Diagnosis and Prognosis of the Alzheimer's Disease
Current Alzheimer Research