Abstract
Abstract: Background: Iron-sulfur clusters are inorganic prosthetic groups composed of only iron and inorganic sulfur atoms. Organisms develop different pathways to sense their local environment and to respond and adapt to changes.
Objective: We focused on Fe-S-containing proteins, which control their activity in response to redox signals by changing the redox state of their cluster. Result: When reduced, these Fe-S cluster-containing sensors are all inactive. As soon as their cluster perceives a signal that induces its oxidation, they switch to an « active state ». Conclusion: This sensing mechanism efficiently helps cells to turn on survival pathways quickly and recover from stressful conditions.Keywords: Fe-S cluster, sensor, redox state, cellular adaptive response, mitoNEET, iron.
Current Chemical Biology
Title:Fe-S Proteins Acting as Redox Switch: New Key Actors of Cellular Adaptive Responses
Volume: 11 Issue: 2
Author(s): Marie-Pierre Golinelli-Cohen*Cécile Bouton*
Affiliation:
- Institut de Chimie des Substances Naturelles, UPR 2301-CNRS, 1 avenue de la Terrasse 91190 Gif-sur-Yvette, Cedex,France
- Institut de Chimie des Substances Naturelles, UPR 2301-CNRS, 1 avenue de la Terrasse 91190 Gif-sur-Yvette, Cedex,France
Keywords: Fe-S cluster, sensor, redox state, cellular adaptive response, mitoNEET, iron.
Abstract: Abstract: Background: Iron-sulfur clusters are inorganic prosthetic groups composed of only iron and inorganic sulfur atoms. Organisms develop different pathways to sense their local environment and to respond and adapt to changes.
Objective: We focused on Fe-S-containing proteins, which control their activity in response to redox signals by changing the redox state of their cluster. Result: When reduced, these Fe-S cluster-containing sensors are all inactive. As soon as their cluster perceives a signal that induces its oxidation, they switch to an « active state ». Conclusion: This sensing mechanism efficiently helps cells to turn on survival pathways quickly and recover from stressful conditions.Export Options
About this article
Cite this article as:
Golinelli-Cohen Marie-Pierre*, Bouton Cécile*, Fe-S Proteins Acting as Redox Switch: New Key Actors of Cellular Adaptive Responses, Current Chemical Biology 2017; 11 (2) . https://dx.doi.org/10.2174/2212796811666170406163809
DOI https://dx.doi.org/10.2174/2212796811666170406163809 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
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