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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Immune System Modulators with Antidepressant Effects: Evidence from Animal Models

Author(s): Helena M. Abelaira, Amanda L. Maciel, Joao Quevedo and Gislaine Z. Reus*

Volume 16, Issue 4, 2017

Page: [398 - 406] Pages: 9

DOI: 10.2174/1871527316666170404141620

Price: $65

Abstract

Background: Major depressive disorder (MDD) is associated with high mortality and morbidity rates, and currently, approximately 340 million people worldwide suffer from depression at some point in life. In view of the growing socio-economic and clinical impact, several studies have focused on the etiopathology of MDD, suggesting that not only the monoaminergic system but also other brain mechanisms may be involved in the pathophysiology of MDD. Recent studies have shown a link between inflammation and MDD and have also demonstrated that antidepressants and antiinflammatory drugs can act to reduce inflammation, thereby improving depressive symptoms. Animal models of depression are indispensable for studying the pathophysiology of this disorder and new treatments for it. Further, studies have shown that rodent models of depression are also associated with elevated levels of inflammation in the periphery and brain.

Objective: This review will highlight the role of immune inflammation in MDD and the significance of immune system modulators with antidepressant effects in the treatment of MDD, based on studies using animal models of depression.

Keywords: Antidepressants, anti-inflammatory drugs, immune system, animal model of depression, major depressive disorder.

Graphical Abstract

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