摘要
超性欲指的是对任何性活动的异常增加或极端参与。它在临床上具有挑战性,呈现出反式诊断,并且有大量的医学文献涉及这一临床综合征的疾病分类学、病机和神经精神病学方面。分类包括异常行为,与冲动有关的可诊断实体,以及强迫性现象。一些临床医生认为性欲的增加是“正常的”,即精神动力理论家认为它是自我防御,有时是缓解植根于心理冲突中的无意识焦虑。我们强调超性行为是多维度的,它涉及到性活动的增加,而性活动与痛苦和功能受损有关。高性欲的病因是多因素的,包括主要的精神疾病(如双相情感障碍)、治疗的不良影响(例如左旋多巴治疗)、物质诱导的疾病(例如苯丙胺类物质的使用)、神经病理障碍(例如额叶综合征)等。许多神经递质参与其发病机制,多巴胺和去甲肾上腺素在神经奖赏通路和情绪调节的边缘系统神经回路中起着至关重要的作用。高性欲的治疗是由有效消失的原理决定的,如果治疗原因,效果可能会消失。我们的目的是回顾药理学药物导致性欲亢进的作用,以及集中作用的药物治疗相关的潜在药物。条件。生物-心理-社会决定因素在理解和指导这一复杂和多决定的临床综合征的管理中起着关键的作用。
关键词: 性欲亢进,正常,神经精神病学,生物心理治疗,神经生物学,性欲。
Current Drug Targets
Title:Hypersexuality As a Neuropsychiatric Disorder: The Neurobiology and Treatment Options
Volume: 19 Issue: 12
关键词: 性欲亢进,正常,神经精神病学,生物心理治疗,神经生物学,性欲。
摘要: Hypersexuality refers to abnormally increased or extreme involvement in any sexual activity. It is clinically challenging, presents trans-diagnostically and there is extensive medical literature addressing the nosology, pathogenesis and neuropsychiatric aspects in this clinical syndrome. Classification includes deviant behaviours, diagnosable entities related to impulsivity, and obsessional phenomena. Some clinicians view an increase in sexual desire as ‘normal’ i.e. psychodynamic theorists consider it as egodefensive at times alleviating unconscious anxiety rooted in intrapsychic conflicts. We highlight hypersexuality as multi-dimensional involving an increase in sexual activity that is associated with distress and functional impairment. The aetiology of hypersexuality is multi-factorial with differential diagnoses that include major psychiatric disorders (e.g. bipolar disorder), adverse effects of treatments (e.g. levodopatreatment), substance-induced disorders (e.g. amphetamine substance use), neuropathological disorders (e.g. frontal lobe syndrome), among others. Numerous neurotransmitters are implicated in its pathogenesis, with dopamine and noradrenaline playing a crucial role in the neural reward pathways and emotionally- regulated limbic system neural circuits. The management of hypersexuality is determined by the principle of de causa effectu evanescent, if the causes are treated, the effect may disappear. We aim to review the role of pharmacological agents causing hypersexuality and centrally acting agents treating the associated underlying medical conditions. Bio-psycho-social determinants are pivotal in embracing the understanding and guiding management of this complex and multi-determined clinical syndrome.
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Hypersexuality As a Neuropsychiatric Disorder: The Neurobiology and Treatment Options, Current Drug Targets 2018; 19 (12) . https://dx.doi.org/10.2174/1389450118666170321144931
DOI https://dx.doi.org/10.2174/1389450118666170321144931 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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