摘要
摘要: 背景:压力通过多种机制参与记忆障碍,包括激活下丘脑 - 垂体轴,从而激活血液中皮质酮的释放。胆碱能系统被毒蕈碱拮抗剂,东莨菪碱阻断也会损害记忆。 目的:本研究旨在探讨姜黄素(20mg / kg)对胆碱能阻滞小鼠应激模型学习记忆和胆碱能系统的影响。 方法:使用东莨菪碱在小鼠中诱导限制性应激并阻断胆碱能受体。用姜黄(也进行NMR分析的姜黄根粉末)处理动物,并研究学习和社会行为。姜黄素对胆碱能毒蕈碱受体(mAChR; M1,M3和M5)基因表达的影响通过RT-PCR在前额叶皮质和海马前两者中进行评估。 结果:姜黄素,姜黄素和α-亚麻酸是姜黄提取物中的铅化合物。与对照组相比,应激小鼠观察到血清皮质酮水平升高,而姜黄治疗显着降低血清皮质酮水平。在强调动物的莫里斯水迷宫测试中,姜黄治疗引起了学习和记忆的改善。在姜黄治疗的动物中也恢复了社会新奇性。姜黄治疗后,M5表达在皮层改善,M3表达在应激+东莨菪碱+姜黄治疗组海马中有改善。 结论:这些发现通过增加M3,M5的表达,改善学习和记忆,突出了姜黄的治疗作用。姜黄可以成为治疗由压力引起的遗忘症的有效候选者。
关键词: 皮质酮,社会行为,胆碱能系统,东莨菪碱,姜黄。
Current Drug Targets
Title:Pharmacological Effects of Turmeric on Learning, Memory and Expression of Muscarinic Receptor Genes (M1, M3 and M5) in Stress-induced Mouse Model
Volume: 18 Issue: 13
关键词: 皮质酮,社会行为,胆碱能系统,东莨菪碱,姜黄。
摘要: Abstract: Background: Stress is involved in memory impairment through multiple mechanisms, including activation of hypothalamic-pituitary axis, which in turn activates release of corticosterone in blood. Cholinergic system blockade by the muscarinic antagonist, scopolamine, also impairs memory.
Objective: This study aimed to investigate the effect of turmeric (20mg/kg) on learning and memory and cholinergic system in a mouse model of stress along with cholinergic blockade. Methods: Restrained stress was induced and cholinergic receptors were blocked using scopolamine in mice. Animals were treated with turmeric (turmeric rhizome powder which was also subjected to NMR analyses) and learning and social behavior was examined. Effect of turmeric on cholinergic muscarinic receptors (mAChR; M1, M3 and M5) gene expression was assessed by RT-PCR in both pre-frontal cortex and hippocampus. Results: Ar-turmerone, curcuminoids and α-linolenic acid were the lead compounds present in turmeric extract. Increased serum corticosterone levels were observed in stressed mice when compared to the control group, while turmeric treatment significantly reduced serum corticosterone level. Turmeric treatment caused an improved learning and memory in Morris water maze test in stressed animals. Social novelty preference was also restored in turmeric treated animals. Following turmeric treatment, M5 expression was improved in the cortex and M3 expression was improved in the hippocampus of stress + scopolamine + turmeric treated group. Conclusions: These findings highlight the therapeutic role of turmeric by increasing the expression of M3, M5 and improving learning and memory. Turmeric can be an effective candidate for the treatment of amnesia caused by the stress.Export Options
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Cite this article as:
Pharmacological Effects of Turmeric on Learning, Memory and Expression of Muscarinic Receptor Genes (M1, M3 and M5) in Stress-induced Mouse Model, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450118666170315120627
DOI https://dx.doi.org/10.2174/1389450118666170315120627 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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