Abstract
The zebrafish is fast becoming a leading and prominent model organism used by researchers for developmental biology, and research in modeling human diseases in zebrafish is being undertaken at a fast pace. Many therapeutic areas, including oncology and cardiovascular diseases to name a few all have zebrafish models based on known disease mechanisms that are translatable to modes of action in humans. Many novel assays have been and are continuing to be developed to study human disease in zebrafish. Prominent methods to identify novel drug targets within the organism include, chemical mutagenesis, insertional mutagenesis and high throughput small molecule screens. Methods to validate potential drug targets include reverse and forward genetics, transgenesis and gene knockout. This review summarizes the important contributions made using the zebrafish model in recent years to aid in drug discovery and target validations in the highly important medical field of cancer medicine, cardiovascular disease and the emerging role of the zebrafish model as a platform for toxicity screening.
Keywords: Zebrafish, Drug, Screening, Drug discovery, In vivo model, ADME.
Current Topics in Medicinal Chemistry
Title:The Use of the Zebrafish Model to Aid in Drug Discovery and Target Validation
Volume: 17 Issue: 18
Author(s): Prusothman Yoganantharjah and Yann Gibert*
Affiliation:
- Metabolic Research Unit, Metabolic Genetic Diseases Laboratory, Deakin University School of Medicine, 75 Pigdons Road, Geelong VIC 3216,Australia
Keywords: Zebrafish, Drug, Screening, Drug discovery, In vivo model, ADME.
Abstract: The zebrafish is fast becoming a leading and prominent model organism used by researchers for developmental biology, and research in modeling human diseases in zebrafish is being undertaken at a fast pace. Many therapeutic areas, including oncology and cardiovascular diseases to name a few all have zebrafish models based on known disease mechanisms that are translatable to modes of action in humans. Many novel assays have been and are continuing to be developed to study human disease in zebrafish. Prominent methods to identify novel drug targets within the organism include, chemical mutagenesis, insertional mutagenesis and high throughput small molecule screens. Methods to validate potential drug targets include reverse and forward genetics, transgenesis and gene knockout. This review summarizes the important contributions made using the zebrafish model in recent years to aid in drug discovery and target validations in the highly important medical field of cancer medicine, cardiovascular disease and the emerging role of the zebrafish model as a platform for toxicity screening.
Export Options
About this article
Cite this article as:
Yoganantharjah Prusothman and Gibert Yann*, The Use of the Zebrafish Model to Aid in Drug Discovery and Target Validation, Current Topics in Medicinal Chemistry 2017; 17 (18) . https://dx.doi.org/10.2174/1568026617666170130112109
DOI https://dx.doi.org/10.2174/1568026617666170130112109 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Adaptogens—History and Future Perspectives
Adaptogens are pharmacologically active compounds or plant extracts that are associated with the ability to enhance the body’s stability against stress. The intake of adaptogens is associated not only with a better ability to adapt to stress and maintain or normalise metabolic functions but also with better mental and physical ...read more
AlphaFold in Medicinal Chemistry: Opportunities and Challenges
AlphaFold, a groundbreaking AI tool for protein structure prediction, is revolutionizing drug discovery. Its near-atomic accuracy unlocks new avenues for designing targeted drugs and performing efficient virtual screening. However, AlphaFold's static predictions lack the dynamic nature of proteins, crucial for understanding drug action. This is especially true for multi-domain proteins, ...read more
Artificial intelligence for Natural Products Discovery and Development
Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Status Epilepticus: An Overview
Current Drug Metabolism Pulmonary Disease in Beta-Thalassemia
Current Respiratory Medicine Reviews Hypotensive Agents from Snake Venoms
Current Drug Targets - Cardiovascular & Hematological Disorders Antiplatelet Therapy in Acute Coronary Syndromes. Evidence Based Medicine
Current Pharmaceutical Design Indications for Heart Transplantation in Congenital Heart Disease
Current Cardiology Reviews Atrial Fibrillation in Autoimmune Rheumatic Diseases: from Pathogenesis to Treatment
Reviews on Recent Clinical Trials Adipose-Derived Stromal/Stem Cells (ASC) in Regenerative Medicine: Pharmaceutical Applications
Current Pharmaceutical Design Role of Oxidative Stress in Polycystic Ovary Syndrome
Current Women`s Health Reviews MicroRNAs in Cardiovascular Therapeutics
Current Topics in Medicinal Chemistry Reconciling the Gap between Medications and their Potential Leads: The Role of Marine Metabolites in the Discovery of New Anticancer Drugs: A Comprehensive Review
Current Pharmaceutical Design Hypertension in Diabetes: Optimal Pharmacotherapy
Cardiovascular & Hematological Agents in Medicinal Chemistry Editorial from Editor-in-Chief: COPD Readmission Rate Penalty: Double Edge Sword, Emphasizing Innovations
Current Respiratory Medicine Reviews The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways
Current Drug Metabolism Protective Effect of Vitamin B Therapy on Bone and Cardiovascular Disease
Recent Patents on Cardiovascular Drug Discovery ADAM9 as a Potential Target Molecule in Cancer
Current Pharmaceutical Design Angiotensin (1-7) and other Angiotensin Peptides
Current Pharmaceutical Design Mitochondrial Dynamics: An Emerging Paradigm in Ischemia-Reperfusion Injury
Current Pharmaceutical Design Differential Influence of Carotid Stenosis and White Matter Disease on Motor and Cognitive Activation
Current Alzheimer Research Nutraceuticals and Dietary Supplements to Improve Quality of Life and Outcomes in Heart Failure Patients
Current Pharmaceutical Design Contribution of Catecholamine Reactive Intermediates and Oxidative Stress to the Pathologic Features of Heart Diseases
Current Medicinal Chemistry