Abstract
Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.
Keywords: Sumoylation, neurological diseases, neuronal function, synapse formation.
Current Molecular Medicine
Title:SUMOylation in Neurological Diseases
Volume: 16 Issue: 10
Author(s): F.-Y. Liu, Y.-F. Liu, Y. Yang, Z.-W. Luo, J.-W. Xiang, Z.-G. Chen, R.-L. Qi, T.-H. Yang, Y. Xiao, W.-J. Qing and D. W.-C. Li
Affiliation:
Keywords: Sumoylation, neurological diseases, neuronal function, synapse formation.
Abstract: Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.
Export Options
About this article
Cite this article as:
Liu F.-Y., Liu Y.-F., Yang Y., Luo Z.-W., Xiang J.-W., Chen Z.-G., Qi R.-L., Yang T.-H., Xiao Y., Qing W.-J. and Li W.-C. D., SUMOylation in Neurological Diseases, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524017666170109125256
DOI https://dx.doi.org/10.2174/1566524017666170109125256 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Multiple Sclerosis – Established and Novel Therapeutic Approaches
Central Nervous System Agents in Medicinal Chemistry Novel Agents, Combinations and Sequences for the Treatment of Advanced Renal Cell Carcinoma: When is the Revolution Coming?
Current Cancer Drug Targets Dermatological, Cardiovascular and Neurological Morphohistopathological Effects of Fluoropyrimidine-based Chemotherapy in Humans
Clinical Cancer Drugs Herpes Simplex Encephalitis: From Virus to Therapy
Infectious Disorders - Drug Targets Intracranial MR Dynamics in Clinically Diagnosed Alzheimers Disease: The Emerging Concept of “Pulse Wave Encephalopathy”
Current Alzheimer Research The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems
Current Drug Targets Quantitative Structure Activity Relationship Studies of Piperazinyl Phenylalanine Derivatives as VLA-4/VCAM-1 Inhibitors
Medicinal Chemistry Transgenic Mice as a Model for Alzheimers Disease
Current Alzheimer Research HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): Still an Obscure Disease
Central Nervous System Agents in Medicinal Chemistry The Cytokine Network in HIV Infection
Current Molecular Medicine Drugs and Aggression
Recent Patents on CNS Drug Discovery (Discontinued) Rheumatoid Arthritis: An Evolutionary Force in Biologics
Current Pharmaceutical Design Could Better Phenotyping Small Vessel Disease Provide New Insights into Alzheimer Disease and Improve Clinical Trial Outcomes?
Current Alzheimer Research Neuro-AIDS: Current Status and Challenges to Antiretroviral Drug Therapy (ART) for Its Treatment
Current Drug Therapy Opiate Drug Use and the Pathophysiology of NeuroAIDS
Current HIV Research Pathology of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Immunosuppressant Drugs and Covid-19: Associated Risks, Drug-Drug Interactions and Contraindications
Coronaviruses GEMSP: A New Therapeutic Approach to Multiple Sclerosis
Central Nervous System Agents in Medicinal Chemistry Therapeutic Use of Brentuximab Vedotin in CD30+ Hematologic Malignancies
Anti-Cancer Agents in Medicinal Chemistry HELLP Syndrome: Pathophysiology and Current Therapies
Current Pharmaceutical Biotechnology