摘要
背景:感染人乳头状瘤病毒(HPV)引起多种恶性肿瘤,约占人类癌症的10-20%。最近开发的两种预防病毒感染的疫苗具有很强的免疫原性,可以提供长期保护。这些疫苗的使用大大降低了全世界妇女第二常见的癌症宫颈的发病率。然而,治疗疫苗可以消除已经存在的人乳头状瘤病毒感染和治疗现有的人乳头状瘤病毒引起的癌症,但是这些疫苗尚未开发。 方法:在这个简单的综述中,我们讨论了人乳头状瘤病毒相关癌症的免疫疗法和对人乳头状瘤病毒感染的免疫病理学的认识的进展。 结果:最近的研究进展表明,人乳头状瘤病毒感染引起的癌症以分子生物学方法靶向免疫治疗对于免疫治疗疫苗的开发有很大的潜力和前景。到目前为止,所测试的免疫疫苗绝大多数是针对人乳头状瘤病毒病毒的基因及其蛋白,尤其是E6和E7癌基因。 结论:发展的免疫疫苗的目的是提高细胞免疫功能,增强的细胞免疫就增强了机体抵御疾病和机体的自然防御能力,从而治疗现有的癌症。
关键词: 免疫治疗,人乳头状瘤病毒,免疫病理机制,癌症,病毒感染,免疫原性,免疫治疗。
Current Cancer Drug Targets
Title:Molecular Approaches Target to Immunotherapy for HPV-Associated Cancers
Volume: 17 Issue: 6
关键词: 免疫治疗,人乳头状瘤病毒,免疫病理机制,癌症,病毒感染,免疫原性,免疫治疗。
摘要: Background: Infection with human papillomavirus (HPVs) causes many cancers, which account for about 10-20% of total human cancers. Two recently developed prophylactic vaccines against virus infection confer strong immunogenicity to provide long-term protection. The use of these vaccines has contributed to a substantial decrease in the rates of cervical cancer the second most common cancer of women worldwide. However, therapeutic vaccines that can eliminate preexisting HPV infections and treat an existing HPV-caused cancer have not been developed.
Method: In this short review, we discuss development of immunotherapy for HPV-associated cancers and recent progresses in our understanding of the immunopathology of HPV infection. Results: Recent research advances have shown that molecular approaches target to immunotherapy for HPV infection-induced cancers to have the great potential and promise for developing immunotherapeutic vaccines. So far, the vast majority of the immunotherapeutic vaccines that are being tested are designed to target HPV viral genes and their proteins especially two E6 and E7 oncogenes. Conclusion: The developing immunotherapeutic vaccines aim to boost cell-mediated immunity. The boosted cell-mediated immunity strengthens the body’s natural defenses to fight active infection and disease, thus to treat the existing cancers.Export Options
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Cite this article as:
Molecular Approaches Target to Immunotherapy for HPV-Associated Cancers, Current Cancer Drug Targets 2017; 17 (6) . https://dx.doi.org/10.2174/1568009616666161216094701
DOI https://dx.doi.org/10.2174/1568009616666161216094701 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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