摘要
近年来,分子遗传学的重大发展有助于理解白血病和白血病不同的亚型分类。确诊为急性白血病的患者通常接受化疗,包括诱导缓解、巩固缓解和维持治疗。由于白血病细胞对化疗药物的敏感性不同,患者仍易复发,因为细胞中活性药物的清除,改善了DNA损伤修复或凋亡通路的异常。细胞黏附和miRNA表达水平也影响耐药性。现一直在寻找新的候选基因和与疾病相关的基因以增加白血病患者的生存率。候选基因通常是位于某一染色体区域中的一个位点,被怀疑参与疾病过程或其表达产物调节疾病的进展。寻找候选基因有经典的和数字化方法。这些技术廉价而快速并容易执行。不幸的是,由于对疾病的病因的认识的不足和低的准确度,研究人员不能检测所有参与白血病形成和细胞抵抗的基因。目前,科学家有许多用于选择基因的工具,如表达微阵列、比较基因组杂交和下一代测序。在候选基因的验证技术中,最常用的是荧光原位杂交法和实时PCR。本篇综述里,我们提出了18个治疗儿童白血病的耐药性的候选基因。
关键词: 数量性状位点(QTL),多种药的耐药,全基因组关联研究(GWAS),连锁图谱的方法、基因图谱、生物标志物。
Current Cancer Drug Targets
Title:New Candidate Genes for Lack of Sensitivity to Therapy in Pediatric Leukemias
Volume: 17 Issue: 4
关键词: 数量性状位点(QTL),多种药的耐药,全基因组关联研究(GWAS),连锁图谱的方法、基因图谱、生物标志物。
摘要: In the recent years, significant development of molecular genetics has contributed to the better understanding of leukemogenesis and classification of the different leukemia subtypes. Patients diagnosed with acute leukemia usually undergo chemotherapy, which involves the induction of remission, consolidation of remission and maintenance therapy. Patients are still vulnerable to relapse due to differences in the sensitivity of leukemia cells to the chemotherapeutic agent, because of the active drugs removal from the cells, improving the repair of DNA damage or abnormalities in the apoptotic pathway. Cell adhesion and miRNA expression level also affect the drug resistance. New candidate genes and genes correlated with the disease have been sought to increase the survival of patients with leukemia. Candidate gene is usually a loci located in a certain chromosomal region suspected of involvement to the disease course or its expression product regulates disease progression. There are classic and digital methods of finding candidate genes. These techniques are inexpensive, quick and easy to carry out. Unfortunately, due to insufficient knowledge of the disease etiology and low accuracy, researchers cannot detect all genes, involved in leukemogenesis and cell resistance. Currently, scientists have many tools used for selecting genes, such as expression microarrays, comparative genomic hybridization and next generation sequencing. Among the validation techniques for candidate genes, the mostly used ones are fluorescent in situ hybridization and real-time PCR. In our review we present 18 candidate genes of resistance to therapy in childhood leukemia.
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New Candidate Genes for Lack of Sensitivity to Therapy in Pediatric Leukemias, Current Cancer Drug Targets 2017; 17 (4) . https://dx.doi.org/10.2174/1568009616666161208150148
DOI https://dx.doi.org/10.2174/1568009616666161208150148 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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