摘要
绿脓杆菌是囊性纤维化患者中最常见的与院内感染和威胁生命的慢性感染有关的格兰性阴性菌。这些病原菌能够依附在医疗设备上形成细胞膜,包括规则排列的胞外聚合物。因其强烈地依附在设备的表面以及抗生素治疗固有的弹性,P.aeruginosa对临床药物产生一种比较严重地威胁,并且促进了慢性感染的长久性。在过去的十年微生物膜的研究主要包括在生物膜形成、耐药性和分散中环境信号、基因元素和分子机制的理解。从这些机制的研究中获得的信息对建立根治方法或阻止生物膜的形成很重要。目前,生物膜感染通常由抗生素和外科手术移除,此外被感染设备的频繁更换。此外近期鉴定的特殊的天然资源可作为康生物膜剂来抵抗病原菌。本文将强调近期抵抗体内和体外模型P.aerugunosa生物膜感染的植物源化合物的进展。
关键词: 康生物膜剂,绿脓杆菌,植物化学成分
Current Drug Targets
Title:Plant-derived Compounds as Potential Source of Novel Anti-Biofilm Agents Against Pseudomonas aeruginosa
Volume: 18 Issue: 4
关键词: 康生物膜剂,绿脓杆菌,植物化学成分
摘要: Pseudomonas aeruginosa is the most common Gram-negative bacterium associated with nosocomial and life-threatening chronic infections in cystic fibrosis patients. This pathogen is wellknown for its ability to attach to surfaces of indwelling medical devices to form biofilms, which consist of a regular array of extracellular polymers. Tenaciously bound to the surface of devices and inherently resilient to antibiotic treatment, P. aeruginosa poses a serious threat in clinical medicine and contributes to the persistence of chronic infections. Studies on microbial biofilms in the past decade involved mainly the understanding of environment signals, genetic elements and molecular mechanisms in biofilm formation, tolerance and dispersal. The knowledge obtained from the studies of these mechanisms is crucial in the establishment of strategies to eradicate or to prevent biofilm formation. Currently, biofilm infections are usually treated with combinations of antibiotics and surgical removal, in addition to frequent replacement of the infected device. More recently, specific natural sources have been identified as antibiofilm agents against this pathogen. This review will highlight the recent progress made by plant-derived compounds against P. aeruginosa biofilm infections in both in vitro or in vivo models.
Export Options
About this article
Cite this article as:
Plant-derived Compounds as Potential Source of Novel Anti-Biofilm Agents Against Pseudomonas aeruginosa, Current Drug Targets 2017; 18 (4) . https://dx.doi.org/10.2174/1389450117666161019102025
DOI https://dx.doi.org/10.2174/1389450117666161019102025 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response and/or therapy ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mechanism of Action and Implication of Naphthoquinone as Potent
Anti-trypanosomal Drugs
Current Topics in Medicinal Chemistry Apixaban: A New Player in the Anticoagulant Class
Current Drug Targets Medical Complications in Anorexia and Bulimia Nervosa
Endocrine, Metabolic & Immune Disorders - Drug Targets Critical Illness in Obstetric Patients: Introduction and Epidemiology
Current Women`s Health Reviews Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD+ Precursor Nicotinamide
Current Medicinal Chemistry C-reactive Protein Apheresis in Acute Myocardial Infarction
Current Pharmaceutical Design Persistent Current Blockers of Voltage-Gated Sodium Channels: A Clinical Opportunity for Controlling Metastatic Disease
Recent Patents on Anti-Cancer Drug Discovery Animal Models for Studying Neointima Formation
Current Vascular Pharmacology Realising the Potential of Adaptive Development of Medicines
Reviews on Recent Clinical Trials Role of the heme oxygenase-adiponectin-atrial natriuretic peptide axis in renal function
Current Pharmaceutical Design Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets?
Current Hypertension Reviews In Silico Classification and Prediction of VIP Derivatives as VPAC1/ VPAC2 Receptor Agonists/Antagonists
Combinatorial Chemistry & High Throughput Screening Systematic Review of the Role of Microparticles in Systemic Sclerosis
Current Rheumatology Reviews Unique Coronary Artery Disease Differences in Women as Related to Revascularization
Current Medicinal Chemistry Applications of Artificial Neural Networks in Medical Science
Current Clinical Pharmacology Angiogenesis as a therapeutic target in breast cancer
Mini-Reviews in Medicinal Chemistry Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders
Current Medicinal Chemistry Latest Therapeutic Novelties and Patents in Pulmonary Hypertension
Recent Patents on Cardiovascular Drug Discovery Pathophysiology and Treatment of Obesity Hypertension
Current Pharmaceutical Design The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases
Mini-Reviews in Medicinal Chemistry