α7烟碱乙酰胆碱受体和Aβ相互作用的神经保护和神经毒性影响：阿尔茨海默病的治疗选择

Title:Neuroprotective and Neurotoxic Implications of α7 Nicotinic Acetylcholine Receptor and Aβ Interaction: Therapeutic Options in Alzheimer's Disease

Volume: 18 Issue: 13

关键词: 阿尔茨海默病，α7烟碱受体，Aβ肽，胆碱能，神经保护，神经毒性。

摘要: Background: Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons.

Literature review: The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds to α7 nicotinic acetylcholine receptors (nAChRs) with very high affinity. This discovery has led to extensive exploration of the possible outcomes of this binding, ranging from the subcellular signaling pathways to its effects on behavioral and cognitive functions. Intriguingly, there are conflicting reports about the effects of this Aβ and α7 nAChR interaction; a few studies report a neuroprotective role of this interaction while others claim that it is neurotoxic.

Conclusion: This review focuses on the neurotoxic and neuroprotective effects of Aβ and α7 nAChR interaction and its implications on different cell signaling pathways and other physiological functions. Moreover, the implications this interaction might have on Alzheimer's disease therapy are also discussed.

Cite this article as:

Neuroprotective and Neurotoxic Implications of α7 Nicotinic Acetylcholine Receptor and Aβ Interaction: Therapeutic Options in Alzheimer's Disease, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161005145143

DOI https://dx.doi.org/10.2174/1389450117666161005145143	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592