摘要
简介:阿尔茨海默氏病(AD)是老年痴呆症最常见的原因。由于全球人口老龄化的日益增加,寻找新的治疗方法变得更为紧迫。在过去的20年中,干细胞技术已成为研究和潜在治疗神经退行性疾病越来越有吸引力的选择。一些研究表明了不同类型的干细胞或祖细胞对阿尔茨海默病模型的病理和认知功能的有益影响。小鼠模型是发现新的治方法的重要的研究工具,我们的目的是探讨在转基因(TG)异种移植AD小鼠模型中,人脐带间充质干细胞的可能的治疗潜力。 方法:将人类脐带干细胞直接注射到APP/PS1 TG AD模型小鼠颈动脉。测试该AD模型试验小鼠的脐带干细胞的疗效,并对行为任务(感觉运动和认知测试)和病理免疫组化定量化进行测量。 结果:脐带干细胞对APP/PS1转基因AD模型小鼠的治疗能降低皮层和海马中的认知损失相关的β淀粉样蛋白的负担。 结论:对照组相比人脐带间充质干细胞能减少转基因小鼠模型的AD病理,减少淀粉样蛋白斑块的负担。这一改进病理学与认知和感觉运动能力提高有关。
关键词: 阿尔茨海默病,β-淀粉样蛋白,动物模型,行为学,组织学,干细胞
Current Alzheimer Research
Title:Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease
Volume: 14 Issue: 1
Author(s): Allal Boutajangout, Abdulwahab Noorwali, Hazem Atta, Thomas Wisniewski
Affiliation:
关键词: 阿尔茨海默病,β-淀粉样蛋白,动物模型,行为学,组织学,干细胞
摘要: Introduction: Alzheimer's disease (AD) is the most common cause of dementia. The search for new treatments is made more urgent given its increasing prevalence resulting from the aging of the global population. Over the past 20 years, stem cell technologies have become an increasingly attractive option to both study and potentially treat neurodegenerative diseases. Several investigators reported a beneficial effect of different types of stem or progenitor cells on the pathology and cognitive function in AD models. Mouse models are one of the most important research tools for finding new treatment for AD. We aimed to explore the possible therapeutic potential of human umbilical cord mesenchymal stem cell xenografts in a transgenic (Tg) mouse model of AD.
Methods: APP/PS1 Tg AD model mice received human umbilical cord stem cells, directly injected into the carotid artery. To test the efficacy of the umbilical cord stem cells in this AD model, behavioral tasks (sensorimotor and cognitive tests) and immunohistochemical quantitation of the pathology was performed. Results: Treatment of the APP/PS1 AD model mice, with human umbilical cord stem cells, produced a reduction of the amyloid beta burden in the cortex and the hippocampus which correlated with a reduction of the cognitive loss. Conclusion: Human umbilical cord mesenchymal stem cells appear to reduce AD pathology in a transgenic mouse model as documented by a reduction of the amyloid plaque burden compared to controls. This amelioration of pathology correlates with improvements on cognitive and sensorimotor tasks.Export Options
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Cite this article as:
Allal Boutajangout, Abdulwahab Noorwali, Hazem Atta, Thomas Wisniewski , Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease, Current Alzheimer Research 2017; 14 (1) . https://dx.doi.org/10.2174/1567205013666161004151416
DOI https://dx.doi.org/10.2174/1567205013666161004151416 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
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Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Alzheimer's Disease Drug Development
Alzheimer's disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Despite decades of research, no cure or disease-modifying treatment is available yet. Therefore, the need for developing effective therapies to treat Alzheimer's disease is an urgent matter. This special issue aims to provide a comprehensive overview of ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
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