摘要
背景:类风湿性关节炎(RA)和骨关节炎(OA)是以持续性炎症和关节破坏为特征的广泛风湿性疾病。硫化氢(H2S)是一种在脑,脉管系统和其他器官中具有重要生理功能的内源性气体。最近的研究发现,H2S是炎症性关节疾病的介质。 目的:本综述总结了近期该领域的文献,突出了相关的发展。 结论:几位作者发现,H2S在急性关节炎的啮齿动物模型和RA和OA组织使用人滑膜细胞和关节软骨细胞的体外模型中显示出抗炎,抗分解代谢和/或抗氧化作用。最早的研究使用了快速溶解盐,如NaSH,但GYY4137在生理上产生的硫化氢不久就出现了。最近,还合成了靶向线粒体的新的形成H 2 S的化合物。这些化合物开启了研究H2S在细胞生物能量学中的作用的兴奋机会,通常在关节炎中被改变。当H2S作为硫酸水浴施用时,也获得了积极的结果,值得进一步研究。这些发现表明,外源性补充H2S可能为这些疾病提供可行的治疗选择,特别是OA。
关键词: 炎性关节病,类风湿关节炎,骨关节炎,硫化氢,线粒体,亚硫酸泉水。
Current Drug Targets
Title:Hydrogen Sulfide and Inflammatory Joint Diseases
Volume: 18 Issue: 14
关键词: 炎性关节病,类风湿关节炎,骨关节炎,硫化氢,线粒体,亚硫酸泉水。
摘要: Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in the brain, vasculature and other organs. Recent studies have found H2S to be a mediator in inflammatory joint diseases.
Objective: This review summarizes the recent literature in this area highlighting relevant developments.
Conclusions: Several authors have found that H2S exhibited anti-inflammatory, anti-catabolic and/or anti-oxidant effects in rodent models of acute arthritis and in in vitro models using human synoviocytes and articular chondrocytes from RA and OA tissues. The earliest studies used fast-dissolving salts, such as NaSH, but GYY4137, which produces H2S more physiologically, shortly appeared. More recently still, new H2S-forming compounds that target mitochondria have been synthesized. These compounds open exciting opportunities for investigating the role of H2S in cell bioenergetics, typically altered in arthritides. Positive results have also been obtained when H2S is administered as a sulphurous water bath, an option meriting further study. These findings suggest that exogenous supplementation of H2S may provide a viable therapeutic option for these diseases, particularly in OA.
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Cite this article as:
Hydrogen Sulfide and Inflammatory Joint Diseases, Current Drug Targets 2017; 18 (14) . https://dx.doi.org/10.2174/1389450117666160829112824
DOI https://dx.doi.org/10.2174/1389450117666160829112824 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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