摘要
自噬是由代谢应激或环境变化引发的进化上保守的降解过程。自噬涉及自噬体的形成,其与溶酶体融合并降解包封的细胞内组分,例如长寿和错误折叠的蛋白质,以及细胞内细胞器。自噬与多种生理和病理状况有关,最近涉及免疫和炎症的调节。风湿性疾病是一组以免疫系统功能障碍为特征的疾病,其中身体攻击其自身的组织。如果不治疗,这些疾病会严重威胁人类健康。虽然自身免疫性疾病的潜在病理生理学尚未完全阐明,但自噬与其进展有关。在本文中,我们回顾了自噬的基础知识,以及自噬在风湿性疾病发病机制中的功能作用,包括系统性红斑狼疮(SLE),类风湿性关节炎(RA),克罗恩病和强直性脊柱炎(AS)。此外,我们回顾了自噬和自噬相关基因(Atgs)在先天性和适应性免疫中的作用,以及自噬和细胞凋亡之间的致病性串扰。我们的研究结果应该为自噬在风湿性疾病发病机制中的作用提供有价值的见解。此外,鉴定新型自噬相关靶蛋白可为治疗人类风湿性疾病的药物提供有希望的靶标
关键词: 自噬,风湿性疾病,发病机制,系统性红斑狼疮,类风湿性关节炎,克罗恩病,强直性脊柱炎
Current Drug Targets
Title:The Role of Autophagy in Rheumatic Disease
Volume: 19 Issue: 9
关键词: 自噬,风湿性疾病,发病机制,系统性红斑狼疮,类风湿性关节炎,克罗恩病,强直性脊柱炎
摘要: Autophagy is an evolutionarily conserved degradation process in triggered by metabolic stress or environmental changes. Autophagy involves formation of autophagosomes, which fuse with lysosomes and degrade encapsulated intracellular components, such as long-lived and misfolded proteins, as well as intracellular organelles. Autophagy has been implicated in a wide variety of physiological and pathological conditions, and was recently implicated in the regulation of immunity and inflammation. Rheumatic diseases are a group of disorders characterized by immune system malfunctions in which the body attacks its own tissues. These diseases can seriously threaten human health if untreated. Although the underlying pathophysiology of autoimmune diseases has not yet been fully elucidated, autophagy has been implicated in their progression. In this article, we review the basics of autophagy, and the functional role of autophagy in the pathogenesis of rheumatic diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease and ankylosing spondylitis (AS). Moreover, we reviewed the role of autophagy and autophagy-related genes (Atgs) in innate and adaptive immunity, as well as the pathogenic crosstalk between autophagy and apoptosis. Our findings should provide valuable insights into the role of autophagy in the pathogenesis of rheumatic diseases. In addition, identification of novel autophagy-associated target proteins may offer a promising target for drugs treating human rheumatic disorders.
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The Role of Autophagy in Rheumatic Disease, Current Drug Targets 2018; 19 (9) . https://dx.doi.org/10.2174/1389450117666160819155028
DOI https://dx.doi.org/10.2174/1389450117666160819155028 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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