干细胞保护剂-LSC生物学中新旧视野

Title:Stem Cell Guardians – Old and New Perspectives in LSC Biology

Volume: 18 Issue: 4

关键词: 自我更新，信号，CML，粒细胞白血病干细胞

摘要: The introduction of tyrosine kinase inhibitors in chronic myeloid leukaemia (CML) has revolutionised disease outcome. However, despite this, progression to blast phase disease is high in those that do not achieve complete cytogenetic and major molecular response on standard therapy. As well as BCR-ABL-dependent mechanisms, disease persistence has been shown to play a key role. Disease persistence suggests that, despite a targeted therapeutic approach, BCR-ABL-independent mechanisms are being exploited to sustain the survival of a small population of cells termed leukaemic stem cells (LSCs). Increasing evidence highlights the importance of self-renewal and survival pathways in this process. This review will focus on the role of stem-cell restricted self-renewal pathways, namely Hedgehog, Notch, and Bone Morphogenic Pathway (BMP). Wingless-Int/β-Catenin (Wnt/β-Catenin) signalling will be discussed within a further review in this series in view of its regulatory role in GSK3β. Further to this, we will highlight the role of key transcriptional regulators, namely p53 and c- MYC, in targeting wider deregulated networks.

Cite this article as:

Stem Cell Guardians – Old and New Perspectives in LSC Biology, Current Drug Targets 2017; 18 (4) . https://dx.doi.org/10.2174/1389450117666160712092944