Abstract
Background: In tissue engineering applications, advanced membrane systems provide useful and adaptable biomimetic microenvironment able to sustain cell viability and functions, enabling the delivery and diffusion of biochemical factors, cell nutrients, and products, and mimicking the natural biological extracellular matrix. Proper cell-material interactions favour cell adhesion and trigger cell growth, migration, proliferation, differentiation and functional activation. The wide availability of biocompatible polymers offers the possibility to develop membranes with tuned morphological, physico-chemical, mechanical and transport properties for targeted tissues.
Objective: In this review, an in-depth examination of how the membrane properties are able to influence and direct the cellular morpho-functional behaviour of specific engineered tissues is discussed. Furthermore, an overview of the advanced membrane systems, in different configuration and composition, for the biofabrication of tissues and organs is reported.Keywords: Polymeric membranes, properties, cell-material interactions, biodegradable membranes, non-degradable membranes, biohybrid systems, tissue engineering.
Current Organic Chemistry
Title:Advanced Membrane Systems for Tissue Engineering
Volume: 21 Issue: 17
Author(s): Simona Salerno*, Sabrina Morelli and Loredana De Bartolo
Affiliation:
- Institute on Membrane Technology, National Research Council of Italy, ITM-CNR c/o University of Calabria, via P. Bucci cubo 17/C, I-87036 Rende (CS),Italy
Keywords: Polymeric membranes, properties, cell-material interactions, biodegradable membranes, non-degradable membranes, biohybrid systems, tissue engineering.
Abstract: Background: In tissue engineering applications, advanced membrane systems provide useful and adaptable biomimetic microenvironment able to sustain cell viability and functions, enabling the delivery and diffusion of biochemical factors, cell nutrients, and products, and mimicking the natural biological extracellular matrix. Proper cell-material interactions favour cell adhesion and trigger cell growth, migration, proliferation, differentiation and functional activation. The wide availability of biocompatible polymers offers the possibility to develop membranes with tuned morphological, physico-chemical, mechanical and transport properties for targeted tissues.
Objective: In this review, an in-depth examination of how the membrane properties are able to influence and direct the cellular morpho-functional behaviour of specific engineered tissues is discussed. Furthermore, an overview of the advanced membrane systems, in different configuration and composition, for the biofabrication of tissues and organs is reported.Export Options
About this article
Cite this article as:
Salerno Simona*, Morelli Sabrina and Bartolo De Loredana, Advanced Membrane Systems for Tissue Engineering, Current Organic Chemistry 2017; 21 (17) . https://dx.doi.org/10.2174/1385272820666160617092944
DOI https://dx.doi.org/10.2174/1385272820666160617092944 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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