靶向Hsp90-Cdc37：抑制Hsp90伴侣功能的有希望的治疗策略

Title:Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function

Volume: 18 Issue: 13

关键词: Hsp90 / Cdc37，蛋白质 - 蛋白质相互作用，PPI抑制剂，靶向策略，蛋白激酶。

摘要: Background & Objective: The Hsp90 chaperone protein regulates the folding, maturation and stability of a wide variety of oncoproteins. In recent years, many Hsp90 inhibitors have entered into the clinical trials while all of them target ATPase showing similar binding capacity and kinds of side-effects so that none have reached to the market. During the regulation progress, numerous protein- protein interactions (PPI) such as Hsp90 and client proteins or cochaperones are involved. With the Hsp90-cochaperones PPI networks being more and more clear, many cancerous proteins have been reported to be tightly correlated to Hsp90-cochaperones PPI. Among them, Hsp90-Cdc37 PPI has been widely reported to associate with numerous protein kinases, making it a novel target for the treatment of cancers.

Cite this article as:

Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666160527125522