摘要
类风湿关节炎(RA)是一种慢性全身性疾病的特点是持久性滑膜炎和全身炎症。目前,广泛使用治疗RA的药物有抗风湿药物、生物制剂和糖皮质激素。但因为不良反应以及较高的使用频率和高的治疗成本,他们的临床使用受到了限制。因此,寻找新的候选药物是十分必要的。传统中药(TCM)长时间被用于治疗类风湿性关节炎。近年来,大量的研究表明,某些中药及其活性成分对RA疗效明显。本文对在临床试验或动物试验中对RA有疗效的中药成分进行了批判性的回顾和总结。此外,本文还对化合物的化学结构和它们的活性之间的关系进行了分析并从来源、方法、结果以及相关机制分析等方面对相关研究进行了阐述。现有的研究表明,类风湿性关节炎中医治疗最有效的化合物有生物碱、黄酮、萜类、酚类和醌类。希望本文有助于天然衍生抗风湿化合物物的筛选。
关键词: 影响,类风湿性关节炎,单体化合物,中药,治疗
Current Drug Targets
Title:Functional Components from Nature-Derived Drugs for the Treatment of Rheumatoid Arthritis
Volume: 17 Issue: 14
Author(s): Qin Ma and Jian-Guo Jiang
Affiliation:
关键词: 影响,类风湿性关节炎,单体化合物,中药,治疗
摘要: Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by persistent synovitis and systemic inflammation. Currently, the widely used drugs for the treatment of RA are disease-modifying antirheumatic drugs, biological agents and glucocorticoids. But their clinical use has been limited because of their adverse effects with a high frequency and high cost of treatment. It is essential to find novel candidate agents. Traditional Chinese medicine (TCM) has been used for RA treatment for a long period of time. In recent years, significant amounts of studies have shown that some TCMs and their active ingredients have obvious therapeutic effects on RA. In this review, the compounds in TCMs that have an effect in clinic or animal experiments of RA are critically reviewed and summarized. Moreover, the relationship between chemical structures of the compound and their activities is analyzed. The relevant researches are described from the aspects of source, methods, result, and related mechanism analysis. The existing studies show that most effective compounds in TCM for RA treatment belong to alkaloids, flavonoids, terpenoids, phenols and quinines. It is hoped that the data summarized in this review will be beneficial to the screening of new nature-derived antirheumatic drugs.
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Qin Ma and Jian-Guo Jiang , Functional Components from Nature-Derived Drugs for the Treatment of Rheumatoid Arthritis, Current Drug Targets 2016; 17 (14) . https://dx.doi.org/10.2174/1389450117666160527122233
DOI https://dx.doi.org/10.2174/1389450117666160527122233 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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