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Current Angiogenesis (Discontinued)


ISSN (Print): 2211-5528
ISSN (Online): 2211-5536

Targeting Tumor Angiogenesis in Gastrointestinal Malignancies

Author(s): Paul R. Kunk, Erika Ramsdale and Osama E. Rahma

Volume 4, Issue 1, 2015

Page: [37 - 45] Pages: 9

DOI: 10.2174/221155280401160517170303

Price: $65


Gastrointestinal [GI] malignancies are common and frequently lethal neoplasms. As our understanding of GI cancers deepens, more pathways are discovered that play key roles in tumorigenesis and metastasis. Angiogenesis has emerged as a critical pathway in many cancers, particularly in GI cancers. The discovery of a complex network of signals, including vascular epithelial growth factor [VEGF], led to the emergence of a new class of cancer therapies targeting angiogenesis. Bevacizumab was the first to emerge, gaining US Food and Drug Administration [FDA] approval in 2004 for the treatment of advanced colorectal cancer; since then, several antiangiogenic agents have become clinically available, and numerous others are in clinical or preclinical testing. This review will focus on anti-angiogenesis therapies in GI malignancies.

Keywords: Anti-angiogenesis, bevacizumab, GI cancer, tumor angiogenesis, Tyrosine kinase inhibitor, VEGF.

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