Abstract
Since camel milk has been attributed with various medicinal properties not found in bovine milk, we are systematically examining the differences between different proteins in bovine and camel milk. The purpose of this study is to investigate the structural differences between the bovine and camel α- lactalbumins. α-Lactalbumin is a highly abundant protein present in the milk of all mammalian species. Here we found several structural differences between bovine and camel α-lactalbumins: camel protein is more stable towards thermal and pHmediated denaturation but less stable towards guanidine hydrochloride-mediated unfolding, aggregates faster and is predicted to be more disordered than bovine α- lactalbumin.
Keywords: α-lactalbumin, CD, fluorescence, guanidine hydrochloride-mediated unfolding, aggregation, intrinsically disordered protein.
Protein & Peptide Letters
Title:α-Lactalbumin: Of Camels and Cows
Volume: 23 Issue: 12
Author(s): Jennifer M. Redington, Leonid Breydo, Hussein A. Almehdar, Elrashdy M. Redwan and Vladimir N. Uversky
Affiliation:
Keywords: α-lactalbumin, CD, fluorescence, guanidine hydrochloride-mediated unfolding, aggregation, intrinsically disordered protein.
Abstract: Since camel milk has been attributed with various medicinal properties not found in bovine milk, we are systematically examining the differences between different proteins in bovine and camel milk. The purpose of this study is to investigate the structural differences between the bovine and camel α- lactalbumins. α-Lactalbumin is a highly abundant protein present in the milk of all mammalian species. Here we found several structural differences between bovine and camel α-lactalbumins: camel protein is more stable towards thermal and pHmediated denaturation but less stable towards guanidine hydrochloride-mediated unfolding, aggregates faster and is predicted to be more disordered than bovine α- lactalbumin.
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Cite this article as:
Redington M. Jennifer, Breydo Leonid, Almehdar A. Hussein, Redwan M. Elrashdy and Uversky N. Vladimir, α-Lactalbumin: Of Camels and Cows, Protein & Peptide Letters 2016; 23 (12) . https://dx.doi.org/10.2174/0929866523666160517123738
DOI https://dx.doi.org/10.2174/0929866523666160517123738 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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