细胞凋亡反常-依旧是慢性淋巴细胞白血病发病机制中的一个重要问题吗？

Title:Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia?

Volume: 16 Issue: 8

Author(s): Monika Podhorecka, Arkadiusz Macheta, Maria Bozko, Andrzej Bozko, Nisar P. Malek, Przemyslaw Bozko

Affiliation:

关键词: 细胞凋亡，B细胞，慢性B型淋巴细胞性白血病 ，慢性淋巴细胞白血病，细胞增殖

摘要: Chronic lymphocytic leukemia (CLL), a clonal expansion of B CD5+ cells, is the most common type of adult leukemia in western countries. The accumulation of neoplastic B-cells is primarily caused by prolonged life-span of these cells due to deregulation of apoptosis, and only marginally due to a higher proliferation rate. In spite of numerous reports characterizing particular mechanisms of B-CLL cell apoptosis, still relatively little is known about the complex regulation of this process. Therefore, more detailed research is required to understand the complicated mechanisms and regulatory processes of apoptosis in neoplastic Blymphocytes.

Cite this article as:

Monika Podhorecka, Arkadiusz Macheta, Maria Bozko, Andrzej Bozko, Nisar P. Malek, Przemyslaw Bozko , Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia?, Current Cancer Drug Targets 2016; 16 (8) . https://dx.doi.org/10.2174/1568009616666160427103930