Abstract
PolyADP-ribosylation is a unique posttranslational modification of proteins, involved in various cellular functions including stability of chromatin. PolyADP-ribosylation modifies acceptor proteins with a large negatively charged poly(ADP-ribose) (PAR) to greatly change the structure and function of the acceptor proteins. In addition various specific motifs of proteins were recently found to interact non-covalently with PAR thereby changing the spaciotemporal activity of protein-protein interaction in cells. However, the structure of PAR to which specific protein motifs should bind is not fully characterized. The present work will review the structure, physicochemical properties and quantification of PAR in vivo, with special reference to PAR binding protein modules.
Keywords: Poly(ADP-ribose) binding modules, chain length, branching, poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase.
Current Protein & Peptide Science
Title:Poly(ADP-ribose): Structure, Physicochemical Properties and Quantification In Vivo, with Special Reference to Poly(ADP-ribose) Binding Protein Modules
Volume: 17 Issue: 7
Author(s): Masanao Miwa, Chieri Ida, Sachiko Yamashita, Masakazu Tanaka and Junichi Fujisawa
Affiliation:
Keywords: Poly(ADP-ribose) binding modules, chain length, branching, poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase.
Abstract: PolyADP-ribosylation is a unique posttranslational modification of proteins, involved in various cellular functions including stability of chromatin. PolyADP-ribosylation modifies acceptor proteins with a large negatively charged poly(ADP-ribose) (PAR) to greatly change the structure and function of the acceptor proteins. In addition various specific motifs of proteins were recently found to interact non-covalently with PAR thereby changing the spaciotemporal activity of protein-protein interaction in cells. However, the structure of PAR to which specific protein motifs should bind is not fully characterized. The present work will review the structure, physicochemical properties and quantification of PAR in vivo, with special reference to PAR binding protein modules.
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Cite this article as:
Miwa Masanao, Ida Chieri, Yamashita Sachiko, Tanaka Masakazu and Fujisawa Junichi, Poly(ADP-ribose): Structure, Physicochemical Properties and Quantification In Vivo, with Special Reference to Poly(ADP-ribose) Binding Protein Modules, Current Protein & Peptide Science 2016; 17 (7) . https://dx.doi.org/10.2174/1389203717666160419145246
DOI https://dx.doi.org/10.2174/1389203717666160419145246 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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