Abstract
In recent years, peptide aptamers have emerged as novel molecular tools that are useful for both basic and applied aspects of molecular medicine. Due to their ability to specifically bind to and inactivate a given target protein at the intracellular level, they provide a new experimental strategy for functional protein analyses, both in vitro and in vivo. In addition, by using peptide aptamers as “pertubagens”, they can be employed for genetic analyses, in order to identify biochemical pathways, and their components, that are associated with the induction of distinct cellular phenotypes. Furthermore, peptide aptamers may be developed into diagnostic tools for the detection of a given target protein or for the generation of high-throughput protein arrays. Finally, the peptide aptamer technology has direct therapeutic implications. Peptide aptamers can be used in order to validate therapeutic targets at the intracellular level. Moreover, the peptide aptamer molecules themselves should possess therapeutic potential, both as lead structures for drug design and as a basis for the development of protein drugs.
Keywords: peptide aptamers, yeast two-hybrid, protein-protein interaction, protein therapy, protein transduction, drug design, protein array
Current Molecular Medicine
Title: Peptide Aptamers: Specific Inhibitors of Protein Function
Volume: 4 Issue: 5
Author(s): Felix Hoppe-Seyler, Irena Crnkovic-Mertens, Evangelia Tomai and Karin Butz
Affiliation:
Keywords: peptide aptamers, yeast two-hybrid, protein-protein interaction, protein therapy, protein transduction, drug design, protein array
Abstract: In recent years, peptide aptamers have emerged as novel molecular tools that are useful for both basic and applied aspects of molecular medicine. Due to their ability to specifically bind to and inactivate a given target protein at the intracellular level, they provide a new experimental strategy for functional protein analyses, both in vitro and in vivo. In addition, by using peptide aptamers as “pertubagens”, they can be employed for genetic analyses, in order to identify biochemical pathways, and their components, that are associated with the induction of distinct cellular phenotypes. Furthermore, peptide aptamers may be developed into diagnostic tools for the detection of a given target protein or for the generation of high-throughput protein arrays. Finally, the peptide aptamer technology has direct therapeutic implications. Peptide aptamers can be used in order to validate therapeutic targets at the intracellular level. Moreover, the peptide aptamer molecules themselves should possess therapeutic potential, both as lead structures for drug design and as a basis for the development of protein drugs.
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Cite this article as:
Hoppe-Seyler Felix, Crnkovic-Mertens Irena, Tomai Evangelia and Butz Karin, Peptide Aptamers: Specific Inhibitors of Protein Function, Current Molecular Medicine 2004; 4 (5) . https://dx.doi.org/10.2174/1566524043360519
DOI https://dx.doi.org/10.2174/1566524043360519 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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