摘要
背景:寄生虫感染如利什曼病是一种被忽视的热带病,是一个重大的全球负担,造成高死亡率,特别是在欠发达国家。其细胞内的性质和寄生虫的传播位置,有限数量的化学治疗剂,对一线药物和毒性的抵抗力的增加的发生率,对通过调节现有药物的传递而必须有效管理利什曼原虫感染的科学家构成了巨大的挑战。在过去十年中,已经广泛研究了基于纳米技术的药物递送系统(纳米颗粒,纳米悬浮液,脂质体等)等替代疗法的开发研究,天然产物的使用以及开发抗风险疫苗的研究。 目的:本次审查的重点是治疗策略,现有的杂项药物递送系统和旨在管理的方法以及感染治疗的不同方面,目的是总结当前系统地采用的治疗策略趋势和策略。此外,该文章还包含了一系列专利专利,涉及用于抗风湿疗法的新型化疗药物。 结论:报告的杂项新型药物递送系统以及各种方法似乎是精确,安全和相对有效的;在结果中,可能导致利什曼病治疗的新轨迹。
关键词: 利什曼病,治疗策略,纳米载体,纳米颗粒,脂质体,疫苗,天然产物,专利。
Current Drug Targets
Title:Recent Advances in Nanosystems and Strategies for Managing Leishmaniasis
Volume: 18 Issue: 14
关键词: 利什曼病,治疗策略,纳米载体,纳米颗粒,脂质体,疫苗,天然产物,专利。
摘要: Background: Parasitic infection such as leishmaniasis, a neglected tropical disease, presents a significant global burden which is responsible for high mortality rate especially in less developed countries. Its intracellular nature and disseminated locations of parasite, limited number of chemotherapeutic agents, increasing incidences of resistance to first line drugs and toxicities, pose a great challenge to formulation scientists that have necessitated effective management of leishmanial infection by modulating the delivery of existing drugs. Over the past decade, research on development of alternative treatments such as nanotechnology-based drug delivery systems (nanoparticles, nanosuspensions, liposomes etc.), use of natural products as well as development of antileishmanial vaccine has been extensively investigated.
Objective: The present review focuses on different facets of therapeutic strategies, existing miscellaneous drug delivery systems and approaches intended for management, as well as treatment of the infection, with an objective to summarize the current trends and strategies adopted for antileishmanial therapy in a systematic manner. Moreover, the article encloses an eclectic collection of patents allied to new-fangled chemotherapeutics for antileishmanial therapy.
Conclusion: The reported miscellaneous novel drug delivery systems along with the diverse approaches are seem to be precise, secure and relatively effective; and in an outcome, could lead to the new track for management of leishmaniasis.
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Cite this article as:
Recent Advances in Nanosystems and Strategies for Managing Leishmaniasis, Current Drug Targets 2017; 18 (14) . https://dx.doi.org/10.2174/1389450117666160401124133
DOI https://dx.doi.org/10.2174/1389450117666160401124133 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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