中枢神经系统中的 Rho相关的：神经退行性疾病紊乱的靶向治疗和同工酶不同的作用

Title:ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders

Volume: 18 Issue: 4

关键词: 轴突再生、中枢神经系统、法舒地尔、亚型、LIMK、神经减退性疾病、挑战

摘要: Rho-associated protein kinase (ROCK) is a serine-threonine kinase originally identified as a crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK as a critical component of diverse signaling pathways in neurons. In addition, inhibition of ROCK causes several biological events such as increase of neurite outgrowth, axonal regeneration, and activation of prosurvival Akt. Thus, it has attracted scientist’s strong attentions and considered ROCK as a promising therapeutic target for the treatment of neurodegenerative disorders including Alzheimer disease, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. However, ROCK has two highly homologous isoforms, ROCK1 and ROCK2. Accumulated evidences indicate that ROCK1 and ROCK2 might involve in distinct cellular functions in central nervous system (CNS) and neurodegenerative processes. This review summarizes recent updates regarding ROCK isoformspecific functions in CNS and the progress of ROCK inhibitors in preclinical studies for neurodegenerative diseases.

Cite this article as:

ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders, Current Drug Targets 2017; 18 (4) . https://dx.doi.org/10.2174/1389450117666160401123825