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Abstract
Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations were developed. In this minireview, we summarized the recent progress of cisplatin delivery strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges preventing the development of improved drug formulations were identified, and effective approaches to address these issues were discussed in the context of these recent works.
Keywords: Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy.
Current Cancer Drug Targets
Title:Current Strategy for Cisplatin Delivery
Volume: 16 Issue: 6
Author(s): Zhanguo Yue and Zhiqiang Cao
Affiliation:
Keywords: Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy.
Abstract: Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations were developed. In this minireview, we summarized the recent progress of cisplatin delivery strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges preventing the development of improved drug formulations were identified, and effective approaches to address these issues were discussed in the context of these recent works.
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Cite this article as:
Yue Zhanguo and Cao Zhiqiang, Current Strategy for Cisplatin Delivery, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666160328113006
DOI https://dx.doi.org/10.2174/1568009616666160328113006 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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