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Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Current Strategy for Cisplatin Delivery

Author(s): Zhanguo Yue and Zhiqiang Cao

Volume 16, Issue 6, 2016

Page: [480 - 488] Pages: 9

DOI: 10.2174/1568009616666160328113006

Price: $65

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Abstract

Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations were developed. In this minireview, we summarized the recent progress of cisplatin delivery strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges preventing the development of improved drug formulations were identified, and effective approaches to address these issues were discussed in the context of these recent works.

Keywords: Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy.

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