摘要
Akt kinase是一种存在与三种同工酶中的丝氨酸-苏氨酸激酶,它们位于不同染色体中并且具有不同的表达位点能够规划细胞正常功能的多种细胞过程。尽管这些Akt同工酶有重复的作用,但是它们也有特殊的作用并且有时候它们甚至表现出相反的作用。有各种各样的变化如增殖、过度表达、癌变等都与这些同工酶有关,它们在很大程度上影响肿瘤的发展。此外,这些改变也诱导肿瘤细胞的化学和放射抵抗性,能够阻碍已存在的治疗组分。此外,许多报道称它们有潜力作为有效的预后生物标志物。虽然许多研究已经讨论了Akt激酶蛋白在不同肿瘤中的意义,但是对亚型特异性参与的研究较少,因此需要更多的关注。本文讨论了全面地讨论了不同中肿瘤中Akt同工酶不同的作用并且找到预防和治疗肿瘤的具有巨大前景的靶点。
关键词: Akt1
Current Drug Targets
Title:Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer
Volume: 18 Issue: 4
关键词: Akt1
摘要: Akt kinase is a serine threonine kinase that exists in three isoforms, located in different chromosomes and has distinct sites of expression which orchestrates diverse cellular processes required for normal functioning of the cell. Though, these Akt isoforms have some overlapping actions, but they also have specific roles and interestingly, sometimes they even perform contrasting functions. There are various alterations such as amplification, overexpression, mutation, etc. associated with these isoforms which have great implications in the development of cancer. Moreover, these alterations also induce chemo and radio resistance in cancer cells that impede the existing treatment modules. Furthermore, many reports have shown their potential as efficient prognostic biomarkers. Although, many studies have discussed the implications of Akt kinase proteins in different cancers but in-depth analysis of isoform- specific involvement is least examined and hence demands more attention. This review discusses the divergent roles of Akt isoforms comprehensively in different cancers and finding their immense prospects as potential targets for cancer prevention and treatment.
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Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer, Current Drug Targets 2017; 18 (4) . https://dx.doi.org/10.2174/1389450117666160307145236
DOI https://dx.doi.org/10.2174/1389450117666160307145236 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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