摘要
背景:锂在体内外显示神经保护和神经营养作用。由于其参与海马神经再生和β-淀粉样蛋白和神经原纤维缠结代谢的相互作用,据推测,锂可能潜在地影响到痴呆症的进展。方法:使用PubMed数据库和交叉引用搜索策略,我们的目的是具体确定锂和痴呆症之间关联的人口(队列或病例对照)研究。结果:从大型队列研究的数据表明锂治疗与痴呆症的风险减少或减少痴呆的严重程度有关联。较小的样本量的研究产生更多的变量结果。结论:锂可降低中老年人痴呆的危险性。锂的有益影响可能限定于特定类型的神经退行性过程。
关键词: 阿尔茨海默病、痴呆、锂、神经保护、人口研究,降低风险。
Current Alzheimer Research
Title:Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders
Volume: 13 Issue: 8
Author(s): Markus Donix and Michael Bauer
Affiliation:
关键词: 阿尔茨海默病、痴呆、锂、神经保护、人口研究,降低风险。
摘要: Background: Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development of dementia. Method: Using the PubMed database and cross-reference search strategies our aim was to specifically identify population (cohort or case-control) studies investigating the association between lithium and dementia. Results: Data from large cohort studies suggest an association between lithium treatment and dementia risk reduction or reduced dementia severity. Studies with smaller sample sizes yield more variable findings. Conclusions: Lithium may reduce the risk of dementia among middle-aged and older people. Beneficial lithium effects are possibly limited to specific types of neurodegenerative processes.
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Markus Donix and Michael Bauer , Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders, Current Alzheimer Research 2016; 13 (8) . https://dx.doi.org/10.2174/1567205013666160219112957
DOI https://dx.doi.org/10.2174/1567205013666160219112957 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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