摘要
背景:脉冲药物递送系统(PDDS)在药物递送领域显示出在确定位置和特定时间释放最大量药物的潜在意义。 PDDS主要是具有确定的药物释放停顿期的时间控制递送装置,其不受胃肠道中存在的酸度,碱度,运动性和酶的影响。脉冲药物具有将药物用于治疗在睡眠期间药物剂量至关重要的疾病的药物中的药物,具有较高的第一代谢代谢和在消化道的精确位置吸收的药物。 目标:评论文章,讨论了一般概念,市场配方和专利或脉搏释放技术中的任何其他最新进展。它还强调需要通过脉冲释放治疗的疾病,对草药脉动制剂的各种研究以及PDDS的质量控制方面。 结论:脉搏药物具有将药物用于治疗在睡眠中药物剂量必不可少的疾病的药物,药物在消化道的精确位置具有更高的第一代谢和吸收。
关键词: 脉搏,草药,治疗时间,滞后时间,药物递送,药物形成。
Current Drug Targets
Title:Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review
Volume: 18 Issue: 10
关键词: 脉搏,草药,治疗时间,滞后时间,药物递送,药物形成。
摘要: Background: Pulsatile drug delivery system (PDDS) shows potential significance in the field of drug delivery to release the maximum amount of drug at a definite site and at specific time. PDDS are mainly time controlled delivery devices having a definite pause period for drug release, which is not affected by acidity, alkalinity, motility and enzymes present in the gastrointestinal tract. Pulsatile medication possess the potential to deliver the drugs in the therapy of diseases where drug dose is essential during sleep, drugs having greater first pass metabolism and absorption at precise location in digestive tract.
Objective: The review article, discuss the general concepts, marketed formulations and patents or any other recent advancement in pulsatile release technology. It also highlights on diseases requiring therapy by pulsatile release, various researches on herbal pulsatile formulations and quality control aspects of PDDS. Conclusion: Pulsatile medication possess the potential to deliver the drugs in the therapy of diseases where drug dose is essential during sleep, drugs having greater first pass metabolism and absorption at precise location in digestive tract.Export Options
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Cite this article as:
Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review, Current Drug Targets 2017; 18 (10) . https://dx.doi.org/10.2174/1389450117666160208144343
DOI https://dx.doi.org/10.2174/1389450117666160208144343 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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